Maria Rohm

Nov 21, 2024 | nature.com | Mauricio Berriel Diaz |Maria Rohm |Stephan Herzig

AbstractCancer cachexia is a complex metabolic disorder marked by unintentional body weight loss or ‘wasting’ of body mass, driven by multiple aetiological factors operating at various levels. It is associated with many malignancies and significantly contributes to cancer-related morbidity and mortality.

Apr 22, 2024 | nature.com | Mihail Ivilinov Todorov |Benedikt Wiestler |Marie Piraud |Daniel Rueckert |Maria Rohm |Stephan Herzig | +1 more

AbstractAutomated detection of specific cells in three-dimensional datasets such as whole-brain light-sheet image stacks is challenging. Here, we present DELiVR, a virtual reality-trained deep-learning pipeline for detecting c-Fos+ cells as markers for neuronal activity in cleared mouse brains. Virtual reality annotation substantially accelerated training data generation, enabling DELiVR to outperform state-of-the-art cell-segmenting approaches.

Apr 21, 2024 | flipboard.com | Doris Kaltenecker |Rami Al-Maskari |Moritz Negwer |Luciano Hoeher |Florian Kofler |Mihail I. Todorov | +12 more

Antiques Roadshow 4 hours ago Antiques Roadshow guest exclaims ‘jiminy crickets’ at dirty violin's price tag express.co.uk - Hayley Anderson • 4h An Antiques Roadshow guest thanked his "Aunt Helen) for her dust-ridden violin which turned out to be incredibly important in the world of classical … Pottery 12 hours ago RARE FIND My father-in-law passed down an artifact from 1920 – an expert said it’s a ‘miracle’ it survived and now worth $70,000 The US Sun - Jacob Willeford, Consumer Reporter •...

Sep 25, 2023 | nature.com | Leonie Uhl |Benedetto Daniele Giaimo |Tobias Friedrich |Elisenda Alsina-Sanchis |David Sprinzak |Carolin Mogler | +5 more

AbstractCachexia is a major cause of morbidity and mortality in individuals with cancer and is characterized by weight loss due to adipose and muscle tissue wasting. Hallmarks of white adipose tissue (WAT) remodeling, which often precedes weight loss, are impaired lipid storage, inflammation and eventually fibrosis. Tissue wasting occurs in response to tumor-secreted factors.