Nina Wettschureck

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Articles

Phosphorylation of endothelial histone H3.3 serine 31 by PKN1 links flow-induced signaling to proatherogenic gene expression - Nature Cardiovascular Research

Jan 7, 2025 | nature.com | Sheng Wang |Carsten Kuenne |Stefan Günther |Nina Wettschureck |Young-June Jin |Mohamad Wessam Alnouri

AbstractAtherosclerotic lesions develop preferentially in arterial regions exposed to disturbed blood flow, where endothelial cells acquire an inflammatory phenotype. How disturbed flow induces endothelial cell inflammation is incompletely understood. Here we show that histone H3.3 phosphorylation at serine 31 (H3.3S31) regulates disturbed-flow-induced endothelial inflammation by allowing rapid induction of FOS and FOSB, required for inflammatory gene expression.
RhoA-mediated G12-G13 signaling maintains muscle stem cell quiescence and prevents stem cell loss - Cell Discovery

Jul 15, 2024 | nature.com | Stefan Günther |Nina Wettschureck

AbstractMultiple processes control quiescence of muscle stem cells (MuSCs), which is instrumental to guarantee long-term replenishment of the stem cell pool. Here, we describe that the G-proteins G12-G13 integrate signals from different G-protein-coupled receptors (GPCRs) to control MuSC quiescence via activation of RhoA.

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