Young-June Jin

Jan 7, 2025 | nature.com | Sheng Wang |Carsten Kuenne |Stefan Günther |Nina Wettschureck |Young-June Jin |Mohamad Wessam Alnouri

AbstractAtherosclerotic lesions develop preferentially in arterial regions exposed to disturbed blood flow, where endothelial cells acquire an inflammatory phenotype. How disturbed flow induces endothelial cell inflammation is incompletely understood. Here we show that histone H3.3 phosphorylation at serine 31 (H3.3S31) regulates disturbed-flow-induced endothelial inflammation by allowing rapid induction of FOS and FOSB, required for inflammatory gene expression.