Carsten Kuenne

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Phosphorylation of endothelial histone H3.3 serine 31 by PKN1 links flow-induced signaling to proatherogenic gene expression - Nature Cardiovascular Research

Jan 7, 2025 | nature.com | Sheng Wang |Carsten Kuenne |Stefan Günther |Nina Wettschureck |Young-June Jin |Mohamad Wessam Alnouri

AbstractAtherosclerotic lesions develop preferentially in arterial regions exposed to disturbed blood flow, where endothelial cells acquire an inflammatory phenotype. How disturbed flow induces endothelial cell inflammation is incompletely understood. Here we show that histone H3.3 phosphorylation at serine 31 (H3.3S31) regulates disturbed-flow-induced endothelial inflammation by allowing rapid induction of FOS and FOSB, required for inflammatory gene expression.
Transcriptional profiling unveils molecular subgroups of adaptive and maladaptive right ventricular remodeling in pulmonary hypertension - Nature Cardiovascular Research

Sep 28, 2023 | nature.com | Prakash Chelladurai |Samer Alabed |Carsten Kuenne |Werner Seeger |Mario Looso |Allan Lawrie | +1 more

AbstractRight ventricular (RV) function is critical to prognosis in all forms of pulmonary hypertension. Here we perform molecular phenotyping of RV remodeling by transcriptome analysis of RV tissue obtained from 40 individuals, and two animal models of RV dysfunction of both sexes.

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