Nose Diseases

Aug 11, 2024 | febs.onlinelibrary.wiley.com | Liqin Wang |Mengfan Xu |Qing Zhang |Nose Diseases

Conflict of interest The authors declare no conflict of interest. References 1 & (2015) Relating structure and function of inner hair cell ribbon synapses. Cell Tissue Res 361, 95–114. 2, , , & (2017) The role of insulin-like growth factor 1 in the progression of age-related hearing loss. Front Aging Neurosci 9, 411. 3 & (2011) Tinnitus with a normal audiogram: physiological evidence for hidden hearing loss and computational model. J Neurosci 31, 13452–13457.

Nov 27, 2023 | trialsjournal.biomedcentral.com | Nose Diseases

This multicenter, parallel-arm randomized controlled trial (RCT) study will be conducted by four tertiary referral clinics (Hospital of the Shanghai Jiao Tong University School of Medicine, China): Ninth People’s Hospital, Sixth People’s Hospital, Ruijin Hospital, and Mental Health Center. The study protocol is drafted following the Standard Protocol Items Recommendations for Interventional Trials (SPIRIT) statement (see additional file 1 for the SPIRIT 2013 Checklist) [40].

Sep 27, 2023 | frontiersin.org | Nose Diseases |Throat Diseases |Jose A. Lopez-Escamez

IntroductionSudden sensorineural hearing loss (SSNHL) is characterized by an abrupt onset of sensorineural hearing impairment, involving a decrease of at least 30 dB in hearing across three consecutive frequencies within a span of 72 h. This condition affects an estimated 5 to 20 individuals out of every 100,000 people annually (1). The precise cause of SSNHL remains elusive, but it is widely believed to result from a complex interplay of factors.

Aug 10, 2023 | cancerci.biomedcentral.com | Nose Diseases |Shanghai Jiao Tong

Fadu and Detroit-562 cells were purchased from the Cell Bank of the Chinese Academy of Sciences and kept in a cell incubator with 5% CO2 at 37 °C in high-glucose DMEM (Gibco, Grand Island, NY, USA) containing L-glutamine with 10% fetal bovine serum, penicillin (100 U/mL), and streptomycin (100 U/mL). The CCK-8 assay was used to assess cell viability, proliferation, and drug resistance.

Jul 20, 2023 | frontiersin.org | Nose Diseases |Throat Diseases |Brian McKinnon |Francesco Comacchio

1. Introduction Idiopathic sudden sensorineural hearing loss (ISSNHL) was defined as a sudden hearing loss that occurs within 72 h, and pure tone audiometry results show a decline at least in the three adjacent frequencies (>30 dBHL) without any identifiable cause (1), which may lead to difficulty in speech recognition and sound localization, especially in noisy environments, and has a significant negative impact on the quality of life and mental status of patients (2–4).