Oliver Howes

1 month ago | nature.com | Alessio Giacomel |Daniel Martins |Oliver Howes |Pierluigi Selvaggi |Federico Turkheimer |Ottavia Dipasquale | +1 more

AbstractMolecular neuroimaging techniques, like PET and SPECT, offer invaluable insights into the brain’s in-vivo biology and its dysfunction in neuropsychiatric patients. However, the transition of molecular neuroimaging into diagnostics and precision medicine has been limited to a few clinical applications, hindered by issues like practical feasibility, high costs, and high between-subject heterogeneity of neuroimaging measures.

Jan 5, 2025 | johnmenadue.com | Oliver Howes

No wonder the United Nations is worried. Making one ton of cement emits nearly one ton of carbon dioxide. With an area the size of Paris being built on every week globally, construction contributes heavily to climate change. In Australia, CO2 from building is tipped to double by 2050. In Southeast Asia, climate change spells danger to government aspirations and peoples’ lives.

Apr 30, 2024 | nature.com | Leonardo Sportelli |Daniel Eisenberg |Enrico D’Ambrosio |Michael Gregory |Thomas Hyde |Joel E. Kleinman | +6 more

AbstractThe polygenic architecture of schizophrenia implicates several molecular pathways involved in synaptic function. However, it is unclear how polygenic risk funnels through these pathways to translate into syndromic illness. Using tensor decomposition, we analyze gene co-expression in the caudate nucleus, hippocampus, and dorsolateral prefrontal cortex of post-mortem brain samples from 358 individuals.

Sep 26, 2023 | thelancet.com | Toby Pillinger |Oliver Howes |Christoph U. Correll

Research in contextEvidence before this studyAlthough clinical guidelines stipulate the need for discussion between clinician and patient about antidepressant and antipsychotic side-effects before making prescription decisions, they do not specify how this complex, multidimensional process should be done.

Apr 13, 2023 | biologicalpsychiatryjournal.com | Robert McCutcheon |Paul Harrison |Oliver Howes |South London

Clustering antipsychotics based on receptor affinitiesThe minimum pKi value was 4. This value (‘4’) was subtracted from all pKi values to give a floor score of zero. Next, in the case that a drug was an agonist or partial agonist at a given receptor (as reported in earlier reviews(7Siafis S. Tzachanis D. Samara M. Papazisis G. Antipsychotic Drugs: From Receptor-binding Profiles to Metabolic Side-effects. Curr Neuropharmacol.