Owen J. Sansom

Nov 13, 2024 | nature.com | Christos Kiourtis |Maria Terradas-Terradas |Stephanie May |Anastasia Georgakopoulou |Amy Collins |Eoin D O’Sullivan | +14 more

AbstractCellular senescence is not only associated with ageing but also impacts physiological and pathological processes, such as embryonic development and wound healing. Factors secreted by senescent cells affect their microenvironment and can induce spreading of senescence locally. Acute severe liver disease is associated with hepatocyte senescence and frequently progresses to multi-organ failure. Why the latter occurs is poorly understood.

Jun 3, 2024 | nature.com | Sudhir B. Malla |Ryan Byrne |Natalie Fisher |Petros Tsantoulis |Rachel A. Ridgway |Kathryn L. Gilroy | +17 more

Correction to: Nature Genetics https://doi.org/10.1038/s41588-024-01654-5, published online 13 February 2024In the version of the article initially published, the S:CORT consortium was missing from the author list and has now been added to the HTML and PDF versions of the article.

May 28, 2024 | nature.com | Andreas Dannhorn |Lucy Flint |George Poulogiannis |Simon T. Barry |Owen J. Sansom

AbstractThe landscape of tissue-based imaging modalities is constantly and rapidly evolving. While formalin-fixed, paraffin-embedded material is still useful for histological imaging, the fixation process irreversibly changes the molecular composition of the sample. Therefore, many imaging approaches require fresh-frozen material to get meaningful results.

Feb 26, 2024 | thetimes.co.uk | Owen J. Sansom

Cancer is going to affect almost one in two of us in our lives and the impact of the disease is devastating. The number of global cancer cases is predicted to increase by about 50 per cent by 2040. We are now at a tipping point. The next decade presents a unique opportunity to transform the prevention, diagnosis and treatment of cancer for millions and Scotland is right at the heart of this life-saving work. But the NHS here is under pressure like never before.

Feb 6, 2023 | nature.com | Simon T. Barry |Dmitry I Gabrilovich |Owen J. Sansom

AbstractMyeloid cells are pivotal within the immunosuppressive tumour microenvironment. The accumulation of tumour-modified myeloid cells derived from monocytes or neutrophils — termed ‘myeloid-derived suppressor cells’ — and tumour-associated macrophages is associated with poor outcome and resistance to treatments such as chemotherapy and immune checkpoint inhibitors.