Philip S. Tsao

1 month ago | nature.com | Magdalena Sevilla-Gonzalez |Elizabeth Litkowski |Hyunkyung Kim |Ching-Ti Liu |Chenglong Yu |John McNeil | +12 more

AbstractElevated fasting insulin levels (FI), indicative of altered insulin secretion and sensitivity, may precede type 2 diabetes (T2D) and cardiovascular disease onset. In this study, we group FI-associated genetic variants based on their genetic and phenotypic similarities and identify seven clusters with distinct mechanisms contributing to elevated FI levels.

Jul 5, 2024 | nature.com | Philip S. Tsao

AbstractAbdominal aortic aneurysm has a high heritability and often co-occurs with other cardiometabolic disorders, suggesting shared genetic susceptibility. We investigate this commonality leveraging recent GWAS studies of abdominal aortic aneurysm and 32 cardiometabolic traits.

Oct 16, 2023 | nature.com | Tanmoy Roychowdhury |Derek Klarin |Michael Levin |Joshua M. Spin |Colwyn A. Headley |Noah Tsao | +44 more

AbstractAbdominal aortic aneurysm (AAA) is a common disease with substantial heritability. In this study, we performed a genome-wide association meta-analysis from 14 discovery cohorts and uncovered 141 independent associations, including 97 previously unreported loci. A polygenic risk score derived from meta-analysis explained AAA risk beyond clinical risk factors.

Jul 6, 2023 | nature.com | Minxian Wang |Shoa L. Clarke |Catherine Tcheandjieu |Patrick T. Ellinor |Philip S. Tsao |Yan Sun | +3 more

AbstractIdentification of individuals at highest risk of coronary artery disease (CAD)—ideally before onset—remains an important public health need. Prior studies have developed genome-wide polygenic scores to enable risk stratification, reflecting the substantial inherited component to CAD risk.