Patrick T. Ellinor

Oct 3, 2024 | nature.com | Satoshi Koyama |Xiaoxi Liu |Yoshinao Koike |Keiko Hikino |Masaru Koido |Wei Li | +13 more

AbstractHuman genetic variants are associated with many traits through largely unknown mechanisms. Here, combining approximately 260,000 Japanese study participants, a Japanese-specific genotype reference panel and statistical fine-mapping, we identified 4,423 significant loci across 63 quantitative traits, among which 601 were new, and 9,406 putatively causal variants.

Sep 30, 2024 | nature.com | Soyeon Kim |Jaeyoung Kim |Yeeun Ahn |Injeong Shim |Chamlee Cho |Patrick T. Ellinor | +2 more

AbstractMetabolic syndrome (MetS) is a complex hereditary condition comprising various metabolic traits as risk factors. Although the genetics of individual MetS components have been investigated actively through large-scale genome-wide association studies, the conjoint genetic architecture has not been fully elucidated. Here, we performed the largest multivariate genome-wide association study of MetS in Europe (nobserved = 4,947,860) by leveraging genetic correlation between MetS components.

Jul 6, 2023 | nature.com | Minxian Wang |Shoa L. Clarke |Catherine Tcheandjieu |Patrick T. Ellinor |Philip S. Tsao |Yan Sun | +3 more

AbstractIdentification of individuals at highest risk of coronary artery disease (CAD)—ideally before onset—remains an important public health need. Prior studies have developed genome-wide polygenic scores to enable risk stratification, reflecting the substantial inherited component to CAD risk.