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2 months ago | 
nature.com | Neil Wright |Hannah Fry |Yiping Chen |Huaidong Du |Canqing Yu |Dianjianyi Sun | +6 more
AbstractProteomics offers unique insights into human biology and drug development, but few studies have directly compared the utility of different proteomics platforms. We measured plasma levels of 2168 proteins in 3976 Chinese adults using both Olink Explore and SomaScan platforms. The correlation of protein levels between platforms was modest (median rho = 0.29), with protein abundance and data quality parameters being key factors influencing correlation.
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Oct 28, 2024 | 
mdpi.com | Li Xie |Zhengming Chen |Sheng Yu
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Sep 29, 2024 | 
nature.com | Canqing Yu |Robin G Walters |Zhengming Chen |Dianjianyi Sun
AbstractLittle is known about the prospective association between autosomal mosaic chromosomal alterations (mCAs), a group of large-scale somatic mutations on autosomes, and bladder cancer. Here we utilized data from 99,877 participants who were free of physician-diagnosed cancer at baseline (2004–2008) of the China Kadoorie Biobank to estimate the associations between autosomal mCAs and bladder cancer (ICD-10: C67). A total of 2874 autosomal mCAs events among 2612 carriers (2.6%) were detected.
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Sep 17, 2024 | 
nature.com | Robin G Walters |Zhengming Chen |Maria G. Kakkoura
arising from K. Luo et al. Nature Metabolism https://doi.org/10.1038/s42255-023-00961-1 (2024)In the 2024 January issue of Nature Metabolism, Luo et al.1 reported an inverse association between milk intake and risk of type 2 diabetes (T2D) among individuals who were lactase non-persistent (LNP), as determined by the lactase (LCT) rs4988235 homozygous GG genotype.
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Aug 27, 2024 | 
nature.com | Minghan Qu |Canqing Yu |Iona Y. Millwood |Robin G Walters |Zhengming Chen |Jun Lv | +2 more
AbstractDNA methylation (DNAm) has been implicated in acute coronary syndrome (ACS), but the causality remains unclear in cross-sectional studies. Here, we conduct a prospective epigenome-wide association study of incident ACS in two Chinese cohorts (discovery: 751 nested case-control pairs; replication: 476 nested case-control pairs).
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Aug 8, 2024 | 
nature.com | M. Austin Argentieri |Derrick Bennett |Ashwag Albukhari |Jun Lv |Iona Y. Millwood |Hannah Fry | +6 more
AbstractCirculating plasma proteins play key roles in human health and can potentially be used to measure biological age, allowing risk prediction for age-related diseases, multimorbidity and mortality. Here we developed a proteomic age clock in the UK Biobank (n = 45,441) using a proteomic platform comprising 2,897 plasma proteins and explored its utility to predict major disease morbidity and mortality in diverse populations.
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Jul 23, 2024 | 
nature.com | Wei Gan |Robert Clarke |Masaru Koido |Masahiro Kanai |Yukinori Okada |Yoichiro Kamatani | +7 more
AbstractElevated blood pressure (BP) is major risk factor for cardiovascular diseases (CVD). Genome-wide association studies (GWAS) conducted predominantly in populations of European ancestry have identified >2,000 BP-associated loci, but other ancestries have been less well-studied. We conducted GWAS of systolic, diastolic, pulse, and mean arterial BP in 100,453 Chinese adults. We identified 128 non-overlapping loci associated with one or more BP traits, including 74 newly-reported associations.
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Apr 10, 2024 | 
journals.plos.org | Yajas Shah |Scott Kulm |Jones Nauseef |Zhengming Chen
Loading metrics Open Access Peer-reviewedResearch Article ? This is an uncorrected proof. Citation: Shah Y, Kulm S, Nauseef JT, Chen Z, Elemento O, Kensler KH, et al. (2024) Benchmarking multi-ancestry prostate cancer polygenic risk scores in a real-world cohort. PLoS Comput Biol 20(4): e1011990. https://doi.org/10.1371/journal.pcbi.1011990Editor: Jason A.
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Mar 8, 2024 | 
nature.com | Dianjianyi Sun |Iona Y. Millwood |Robin G Walters |Yiping Chen |Huaidong Du |Zhengming Chen | +1 more
AbstractDespite the high prevalence of snoring in Asia, little is known about the genetic etiology of snoring and its causal relationships with cardiometabolic traits. Based on 100,626 Chinese individuals, a genome-wide association study on snoring was conducted. Four novel loci were identified for snoring traits mapped on SLC25A21, the intergenic region of WDR11 and FGFR, NAA25, ALDH2, and VTI1A, respectively.
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Mar 6, 2024 | 
nature.com | Minna K. Karjalainen |Eeva Sliz |Elias Allara |Weihua Zhang |Pekka Jousilahti |Kati Kristiansson | +46 more
AbstractGenome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism1,2,3,4,5,6,7. This detailed knowledge of the genetic determinants of systemic metabolism has been pivotal for uncovering how genetic pathways influence biological mechanisms and complex diseases8,9,10,11.
