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2 months ago | 
nature.com | Neil Wright |Hannah Fry |Yiping Chen |Huaidong Du |Canqing Yu |Dianjianyi Sun | +6 more
AbstractProteomics offers unique insights into human biology and drug development, but few studies have directly compared the utility of different proteomics platforms. We measured plasma levels of 2168 proteins in 3976 Chinese adults using both Olink Explore and SomaScan platforms. The correlation of protein levels between platforms was modest (median rho = 0.29), with protein abundance and data quality parameters being key factors influencing correlation.
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Aug 27, 2024 | 
nature.com | Minghan Qu |Canqing Yu |Iona Y. Millwood |Robin G Walters |Zhengming Chen |Jun Lv | +2 more
AbstractDNA methylation (DNAm) has been implicated in acute coronary syndrome (ACS), but the causality remains unclear in cross-sectional studies. Here, we conduct a prospective epigenome-wide association study of incident ACS in two Chinese cohorts (discovery: 751 nested case-control pairs; replication: 476 nested case-control pairs).
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Aug 8, 2024 | 
nature.com | M. Austin Argentieri |Derrick Bennett |Ashwag Albukhari |Jun Lv |Iona Y. Millwood |Hannah Fry | +6 more
AbstractCirculating plasma proteins play key roles in human health and can potentially be used to measure biological age, allowing risk prediction for age-related diseases, multimorbidity and mortality. Here we developed a proteomic age clock in the UK Biobank (n = 45,441) using a proteomic platform comprising 2,897 plasma proteins and explored its utility to predict major disease morbidity and mortality in diverse populations.
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Jul 23, 2024 | 
nature.com | Wei Gan |Robert Clarke |Masaru Koido |Masahiro Kanai |Yukinori Okada |Yoichiro Kamatani | +7 more
AbstractElevated blood pressure (BP) is major risk factor for cardiovascular diseases (CVD). Genome-wide association studies (GWAS) conducted predominantly in populations of European ancestry have identified >2,000 BP-associated loci, but other ancestries have been less well-studied. We conducted GWAS of systolic, diastolic, pulse, and mean arterial BP in 100,453 Chinese adults. We identified 128 non-overlapping loci associated with one or more BP traits, including 74 newly-reported associations.
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Mar 8, 2024 | 
nature.com | Dianjianyi Sun |Iona Y. Millwood |Robin G Walters |Yiping Chen |Huaidong Du |Zhengming Chen | +1 more
AbstractDespite the high prevalence of snoring in Asia, little is known about the genetic etiology of snoring and its causal relationships with cardiometabolic traits. Based on 100,626 Chinese individuals, a genome-wide association study on snoring was conducted. Four novel loci were identified for snoring traits mapped on SLC25A21, the intergenic region of WDR11 and FGFR, NAA25, ALDH2, and VTI1A, respectively.
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Feb 6, 2024 | 
biorxiv.org | Sam Morris |Kuang Lin |Iona Y. Millwood |Canqing Yu
AbstractBackgroundPathogens have been one of the primary sources of natural selection affecting modern humans. The footprints of historical selection events ("selective sweeps") can be detected in the genomes of present-day individuals. Previous analyses of 629 samples from the 1000 Genomes Project suggested that an ancient coronavirus epidemic ~20,000 years ago drove multiple selective sweeps in the ancestors of present-day East Asians, but not in other worldwide populations.
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Jan 4, 2024 | 
nature.com | Xiangrui Meng |Daniel F Levey |Dora Koller |Mark Adams |Miguel E. Rentería |Dan Stein | +42 more
AbstractMost genome-wide association studies (GWAS) of major depression (MD) have been conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD, adding data from 21 cohorts with 88,316 MD cases and 902,757 controls to previously reported data. This analysis used a range of measures to define MD and included samples of African (36% of effective sample size), East Asian (26%) and South Asian (6%) ancestry and Hispanic/Latin American participants (32%).
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Dec 13, 2023 | 
nature.com | Pek Kei Im |Anya Topiwala |Zhengming Chen |Iona Y. Millwood |Steven Bell
AbstractAlcohol-related liver disease (ARLD) represents a major public health burden. Identification of high-risk individuals would allow efficient targeting of public health interventions. Here, we show significant interactions between pattern of drinking, genetic predisposition (polygenic risk score, PRS) and diabetes mellitus, and risk of incident ARLD, in 312,599 actively drinking adults in UK Biobank.
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Jun 8, 2023 | 
nature.com | Pek Kei Im |Neil Wright |Yiping Chen |Huaidong Du |Canqing Yu |Robert Clarke | +3 more
Study populationDetails of the CKB study design and methods have been previously reported55. Briefly, 512,724 adults aged 30–79 years were recruited from ten geographically diverse (five rural and five urban) areas across China during 2004–2008.
