Tammy Liu

Jun 10, 2024 | nature.com | JangKeun Kim |Christopher R Chin |Tammy Liu |Irina Matei |Cem Meydan |Masafumi Muratani | +7 more

AbstractIt is now widely recognised that the environment in space activates a diverse set of genes involved in regulating fundamental cellular pathways. This includes the activation of genes associated with blood homeostasis and erythropoiesis, with a particular emphasis on those involved in globin chain production.

Nov 30, 2023 | cell.com | Guy Trudel |Tammy Liu

Abstract Knowledge is rapidly accumulating on basic roles and modulation of bone-marrow adipose tissue (BMAT). Among key modulators are physical forces on bones as exerted by gravity and exercise. Studying humans returning from space has revealed that, in addition to physical forces, local energetics within the bone marrow can play modulatory roles.

Aug 9, 2023 | nature.com | Tammy Liu |Gerd Melkus |Tim Ramsay |Odette Laneuville

AbstractSpace travel requires metabolic adaptations from multiple systems. While vital to bone and blood production, human bone marrow adipose (BMA) tissue modulation in space is unknown. Here we show significant downregulation of the lumbar vertebrae BMA in 14 astronauts, 41 days after landing from six months’ missions on the International Space Station. Spectral analyses indicated depletion of marrow adipose reserves. We then demonstrate enhanced erythropoiesis temporally related to low BMA.