Guy Trudel

Canada

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Articles

The Space Omics and Medical Atlas (SOMA) and international astronaut biobank - Nature

Jun 11, 2024 | nature.com | Eliah G. Overbey |JangKeun Kim |Braden T. Tierney |Jiwoon Park |Deena Najjar |Remi Klotz | +30 more

AbstractSpaceflight induces molecular, cellular, and physiological shifts in astronauts and poses myriad biomedical challenges to the human body, which are becoming increasingly relevant as more humans venture into space1-6. Yet, current frameworks for aerospace medicine are nascent and lag far behind advancements in precision medicine on Earth, underscoring the need for rapid development of space medicine databases, tools, and protocols.
Spatiotemporal expression and control of haemoglobin in space - Nature Communications

Jun 10, 2024 | nature.com | JangKeun Kim |Christopher R Chin |Tammy Liu |Irina Matei |Cem Meydan |Masafumi Muratani | +7 more

AbstractIt is now widely recognised that the environment in space activates a diverse set of genes involved in regulating fundamental cellular pathways. This includes the activation of genes associated with blood homeostasis and erythropoiesis, with a particular emphasis on those involved in globin chain production.
Transcriptomic evidence of erythropoietic adaptation from the International Space Station and from an Earth-based space analog - npj Microgravity

May 12, 2024 | nature.com | Guy Trudel

AbstractSpace anemia affects astronauts and the underlying molecular alterations remain unknown. We evaluated the response of erythropoiesis-modulating genes to spaceflight through the analysis of leukocyte transcriptomes from astronauts during long-duration spaceflight and from an Earth model of microgravity.
Association of Knee Osteoarthritis and Flexion Contracture With Localized Tibial Articular Cartilage Loss: Data From the Osteoarthritis Initiative

Mar 1, 2024 | jrheum.org | T. Mark Campbell |Odette Laneuville |Guy Trudel |T.M. Campbell

Key Indexing Terms:cartilageknee jointmagnetic resonance imagingosteoarthritisrange of motionOsteoarthritis (OA) is the most common form of arthritis, and the knee is the most commonly affected large joint.1 At present, no OA disease-modifying antirheumatic drugs exist, and treatment is palliative.2 With the aging population, OA prevalence is ever-increasing1,2; therefore, novel approaches for knee OA treatment are desperately needed.
People with knee OA and flexion contracture developed localized tibial articular cartilage loss: data from the osteoarthritis initiative

Dec 11, 2023 | jrheum.org | T. Mark Campbell |Odette Laneuville |Guy Trudel |T.M. Campbell

People with knee OA and flexion contracture developed localized tibial articular cartilage loss: data from the osteoarthritis initiative T. Mark Campbell, Odette Laneuville, Guy Trudel The Journal of Rheumatology Dec 2023, jrheum.2023-0743; DOI: 10.3899/jrheum.2023-0743
The ups and downs of bone-marrow adipose tissue in space

Nov 30, 2023 | cell.com | Guy Trudel |Tammy Liu

Abstract Knowledge is rapidly accumulating on basic roles and modulation of bone-marrow adipose tissue (BMAT). Among key modulators are physical forces on bones as exerted by gravity and exercise. Studying humans returning from space has revealed that, in addition to physical forces, local energetics within the bone marrow can play modulatory roles.
Carbon monoxide as a clinical marker of hemolysis

May 26, 2023 | onlinelibrary.wiley.com | Jake Osborne |Guy Trudel |Mohamad Sobh

Abstract Carbon monoxide (CO)-based tests have precisely measured hemolysis for over 40 years. End-tidal CO was the primary marker in clinical hematology research, followed by carboxyhemoglobin. Quantification of CO reflects heme oxygenases degrading heme in a 1:1 stoichiometric ratio, making CO a direct marker of hemolysis. CO in alveolar air can be quantified using gas chromatography, whose high resolution allows detecting mild and moderate levels of hemolysis.

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Guy Trudel

Articles

The Space Omics and Medical Atlas (SOMA) and international astronaut biobank - Nature

Spatiotemporal expression and control of haemoglobin in space - Nature Communications

Transcriptomic evidence of erythropoietic adaptation from the International Space Station and from an Earth-based space analog - npj Microgravity

Association of Knee Osteoarthritis and Flexion Contracture With Localized Tibial Articular Cartilage Loss: Data From the Osteoarthritis Initiative

People with knee OA and flexion contracture developed localized tibial articular cartilage loss: data from the osteoarthritis initiative

The ups and downs of bone-marrow adipose tissue in space

Carbon monoxide as a clinical marker of hemolysis

Contact details

Emails

Socials & Sites