Timothy J. Henrich

Nov 18, 2024 | nature.com | Alton Barbehenn |Vivian Pae |Sannidhi Sarvadhavabhatla |Michael J Peluso |Jeffrey Martin |Frederick M. Hecht | +7 more

AbstractDespite antiretroviral therapy (ART), HIV persists in latently-infected cells (the HIV reservoir) which decay slowly over time. Here, leveraging >500 longitudinal samples from 67 people living with HIV (PLWH) treated during acute infection, we developed a mathematical model to predict reservoir decay from peripheral CD4 + T cells.

Sep 6, 2024 | nature.com | Sara Suliman |David P Maison |Timothy J. Henrich

This Comment discusses the explosion in innovative systems biology approaches in infectious disease studies. We outline the numerous challenges associated with these technologies from standardizing data science approaches to reproducibility of findings, as well as cost.