Jeffrey Martin

Nov 18, 2024 | nature.com | Alton Barbehenn |Vivian Pae |Sannidhi Sarvadhavabhatla |Michael J Peluso |Jeffrey Martin |Frederick M. Hecht | +7 more

AbstractDespite antiretroviral therapy (ART), HIV persists in latently-infected cells (the HIV reservoir) which decay slowly over time. Here, leveraging >500 longitudinal samples from 67 people living with HIV (PLWH) treated during acute infection, we developed a mathematical model to predict reservoir decay from peripheral CD4 + T cells.

Oct 9, 2024 | sciencedirect.com | M. Ahmed |Michael J Peluso |Jeffrey Martin |M.D.H. Hawlader

Persistent symptoms following the acute phase of COVID-19, termed postacute sequelae of COVID-19 (PASC), or long COVID-19, is a multisystemic condition affecting an estimated 10% of individuals following SARS-CoV-2 infection [1]. PASC is associated with a wide array of symptoms representing most organ systems, encompasses a heterogeneous set of pathophysiological processes, and can substantially affect the quality of life [[2], [3], [4]].

Aug 28, 2024 | nature.com | Michael J Peluso |Michelle Davidson |Sarah Goldberg |Jessica Chen |Badri Viswanathan |Kevin C. Donohue | +8 more

AbstractTo understand the roles of acute-phase viral dynamics and host immune responses in post-acute sequelae of SARS-CoV-2 infection (PASC), we enrolled 136 participants within 5 days of their first positive SARS-CoV-2 real-time PCR test. Participants self-collected up to 21 nasal specimens within the first 28 days post-symptom onset; interviewer-administered questionnaires and blood samples were collected at enrollment, days 9, 14, 21, 28, and month 4 and 8 post-symptom onset.

Dec 19, 2023 | cell.com | Lu Zhang |Jeffrey Martin |Rebecca L. Whitehouse

Chemoproteomics has made significant progress in investigating small-molecule-protein interactions. However, the proteome-wide profiling of cysteine ligandability remains challenging to adapt for high-throughput applications, primarily due to a lack of platforms capable of achieving the desired depth using low input in 96- or 384-well plates.

Oct 2, 2023 | nature.com | Daniel Reeves |Mohamed Abdel-Mohsen |Mars Stone |Frederick M. Hecht |Jeffrey Martin |Steven Deeks | +2 more

AbstractPersistence of HIV in people living with HIV (PWH) on suppressive antiretroviral therapy (ART) has been linked to physiological mechanisms of CD4+ T cells. Here, in the same 37 male PWH on ART we measure longitudinal kinetics of HIV DNA and cell turnover rates in five CD4 cell subsets: naïve (TN), stem-cell- (TSCM), central- (TCM), transitional- (TTM), and effector-memory (TEM). HIV decreases in TTM and TEM but not in less-differentiated subsets.