Frederick M. Hecht

Nov 18, 2024 | nature.com | Alton Barbehenn |Vivian Pae |Sannidhi Sarvadhavabhatla |Michael J Peluso |Jeffrey Martin |Frederick M. Hecht | +7 more

AbstractDespite antiretroviral therapy (ART), HIV persists in latently-infected cells (the HIV reservoir) which decay slowly over time. Here, leveraging >500 longitudinal samples from 67 people living with HIV (PLWH) treated during acute infection, we developed a mathematical model to predict reservoir decay from peripheral CD4 + T cells.

Sep 24, 2024 | journals.sagepub.com | Frederick M. Hecht |Rebecca Crane |Patricia Moran |Willem Kuyken

Mindfulness-based approaches such as Mindfulness Based Stress Reduction (MBSR) have gained significant empirical support, showing benefits for the treatment of chronic pain,1 substance use disorders,2,3 anxiety disorders,4 and depression.5 Teacher skill is likely critical to the quality of mindfulness-based interventions (MBIs).

Oct 2, 2023 | nature.com | Daniel Reeves |Mohamed Abdel-Mohsen |Mars Stone |Frederick M. Hecht |Jeffrey Martin |Steven Deeks | +2 more

AbstractPersistence of HIV in people living with HIV (PWH) on suppressive antiretroviral therapy (ART) has been linked to physiological mechanisms of CD4+ T cells. Here, in the same 37 male PWH on ART we measure longitudinal kinetics of HIV DNA and cell turnover rates in five CD4 cell subsets: naïve (TN), stem-cell- (TSCM), central- (TCM), transitional- (TTM), and effector-memory (TEM). HIV decreases in TTM and TEM but not in less-differentiated subsets.