
Trent M Woodruff
Articles
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3 weeks ago |
nature.com | Rhyll E. Smythe |Eduardo A. Albornoz |Jonathan E Noonan |Trent M Woodruff |André Samson |Simone M. Schoenwaelder | +3 more
AbstractMicroangiopathy is a major complication of SARS-CoV-2 infection and contributes to the acute and chronic complications of the disease1. Endotheliopathy and dysregulated blood coagulation are prominent in COVID-19 and are considered to be major causes of microvascular obstruction1,2. Here we demonstrate extensive endothelial cell (EC) death in the microvasculature of COVID-19 organs.
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Apr 17, 2024 |
cell.com | John Lee |Trent M Woodruff
The persistence or recurrence of symptoms after acute SARS-CoV-2 infection, termed ‘long COVID’, presents a formidable challenge to global healthcare systems. Recent research by Cervia-Hasler and colleagues delves into the intricate immunological landscape in patients with long COVID, demonstrating an interplay between complement and coagulation, driven by antiviral antibodies and tissue damage.
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Nov 12, 2023 |
nature.com | Julio Aguado |Atefeh Taherian Fard |Eduardo A. Albornoz |Alexander Tyshkovskiy |Marius Schwabenland |Benjamin Liang | +8 more
AbstractAging is a major risk factor for neurodegenerative diseases, and coronavirus disease 2019 (COVID-19) is linked to severe neurological manifestations. Senescent cells contribute to brain aging, but the impact of virus-induced senescence on neuropathologies is unknown. Here we show that senescent cells accumulate in aged human brain organoids and that senolytics reduce age-related inflammation and rejuvenate transcriptomic aging clocks.
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