Trent M Woodruff

Apr 17, 2024 | cell.com | John Lee |Trent M Woodruff

The persistence or recurrence of symptoms after acute SARS-CoV-2 infection, termed ‘long COVID’, presents a formidable challenge to global healthcare systems. Recent research by Cervia-Hasler and colleagues delves into the intricate immunological landscape in patients with long COVID, demonstrating an interplay between complement and coagulation, driven by antiviral antibodies and tissue damage.

Nov 12, 2023 | nature.com | Julio Aguado |Atefeh Taherian Fard |Eduardo A. Albornoz |Alexander Tyshkovskiy |Marius Schwabenland |Benjamin Liang | +8 more

AbstractAging is a major risk factor for neurodegenerative diseases, and coronavirus disease 2019 (COVID-19) is linked to severe neurological manifestations. Senescent cells contribute to brain aging, but the impact of virus-induced senescence on neuropathologies is unknown. Here we show that senescent cells accumulate in aged human brain organoids and that senolytics reduce age-related inflammation and rejuvenate transcriptomic aging clocks.