André Samson

3 weeks ago | nature.com | Rhyll E. Smythe |Eduardo A. Albornoz |Jonathan E Noonan |Trent M Woodruff |André Samson |Simone M. Schoenwaelder | +3 more

AbstractMicroangiopathy is a major complication of SARS-CoV-2 infection and contributes to the acute and chronic complications of the disease1. Endotheliopathy and dysregulated blood coagulation are prominent in COVID-19 and are considered to be major causes of microvascular obstruction1,2. Here we demonstrate extensive endothelial cell (EC) death in the microvasculature of COVID-19 organs.

Nov 20, 2024 | nature.com | Shene Chiou |Vinzenz Hofferek |Joanne M. Hildebrand |Malcolm J. McConville |Kate Lawlor |Edwin Hawkins | +3 more

AbstractMixed lineage kinase domain-like (MLKL) is a pseudokinase, best known for its role as the terminal effector of the necroptotic cell death pathway. MLKL-mediated necroptosis has long been linked to various age-related pathologies including neurodegeneration, atherosclerosis and male reproductive decline, however many of these attributions remain controversial.

Jun 3, 2024 | nature.com | André Samson |James Murphy

A series of recent studies have established where the necroptosis machinery — RIPK1, RIPK3, MLKL, ZBP1 and Caspase-8 — occur and are activated in mouse and human tissues, and how ZBP1 splicing might regulate necroptosis. These studies highlight the importance of mapping necroptosis spatially to understand how pathway dysregulation can lead to disease.