Volker M Lauschke

Oct 4, 2024 | nature.com | Yi Zhong |Volker M Lauschke

Two recent publications in Nature reveal the detailed structural mechanisms underlying the recognition of infection by the bacterial Phage Anti-Restriction Induced System (PARIS).1,2 These findings are important as they show a new strategy for the recognition of viral infections, shed light on principles of host-virus co-evolution and might pave the way for the development of new antimicrobial strategies.

Aug 18, 2024 | nature.com | Pei Jiang |Volker M Lauschke

AbstractCrizotinib carries an FDA hepatotoxicity warning, yet analysis of the FAERS database suggests that the severity of its hepatotoxicity risks, including progression to hepatitis and liver failure, might be underreported. However, the underlying mechanism remains poorly understood, and effective intervention strategies are lacking.

Mar 27, 2024 | nature.com | Vanessa Monteil |Shane Wright |Sofia Appelberg |Hyesoo Kwon |Ioannis Pittarokoilis |Georg Michlits | +11 more

AbstractClimate change and population densities accelerated transmission of highly pathogenic viruses to humans, including the Crimean–Congo haemorrhagic fever virus (CCHFV). Here we report that the Low Density Lipoprotein Receptor (LDLR) is a critical receptor for CCHFV cell entry, playing a vital role in CCHFV infection in cell culture and blood vessel organoids.

Oct 25, 2023 | nature.com | Vanessa Monteil |Hyesoo Kwon |Cristiano Salata |Gustav Jönsson |Sofia Appelberg |Astrid Hagelkrüys | +7 more

AbstractMarburg and Ebola filoviruses are two of the deadliest infectious agents and several outbreaks have occurred in the last decades. Although several receptors and co-receptors have been reported for Ebola virus, key host factors remain to be elucidated. In this study, using a haploid cell screening platform, we identify the guanine nucleotide exchange factor CCZ1 as a key host factor in the early stage of filovirus replication.