Xin Li

1 month ago | nature.com | Xin Li |Huadong Guo |Guodong Cheng |Youhua Ran |Min Feng |Tao Che | +5 more

AbstractAs important components of global commons, environmental changes in polar regions are crucial to the local and global sustainability. However, they have received little attention in the current framework of sustainable development goals (SDGs). This study examines the impacts of climate change in polar regions, emphasizing the interconnectedness of these areas with other parts of the global system.

1 month ago | nature.com | Xin Li

AbstractDisease relapse is a major cause of treatment failure after allogeneic haematopoietic stem cell transplantation (allo-HSCT) in patients with acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS). We retrospectively evaluated all patients (n = 145) with high-risk AML and MDS who underwent allo-HSCT between 2016 and 2022. Among them, 53 patients received maintenance therapy with azacitidine (AZA), and 10 of these patients received preemptive therapy.

2 months ago | nature.com | Xin Li |Qipeng Yan |Lei Liu

AbstractThe α7 nicotinic acetylcholine receptor (nAChR), a pentameric ligand-gated ion channel, plays important roles in cognition, neuroprotection, and anti-inflammation. As a potential drug target, α7 nAChR has different binding sites for different ligands, particularly agonists and positive allosteric modulators (PAMs). Ago-PAMs can both directly activate and allosterically modulate α7 nAChR. However, the mechanism underlying α7 nAChR modulation by ago-PAM has yet to be fully elucidated.

2 months ago | nature.com | Jie-Ying Zhu |Min Chen |Wang-Jing Mu |Hong-Yang Luo |Shan Li |Lin-Jing Yan | +4 more

AbstractExercise combats obesity and metabolic disorders, but the underlying mechanism is incompletely understood. KLF10, a transcription factor involved in various biological processes, has an undefined role in adipose tissue and obesity. Here, we show that exercise facilitates adipocyte-derived KLF10 expression via SIRT1/FOXO1 pathway.

Feb 9, 2025 | nature.com | Runnan Cao |Cory S Inman |Xin Li |Adam N. Mamelak |Jon Willie

AbstractHow the brain encodes, recognizes, and memorizes general visual objects is a fundamental question in neuroscience. Here, we investigated the neural processes underlying visual object perception and memory by recording from 3173 single neurons in the human amygdala and hippocampus across four experiments. We employed both passive-viewing and recognition memory tasks involving a diverse range of naturalistic object stimuli.