Xin Li

2 weeks ago | nature.com | Xin Li |Qipeng Yan |Lei Liu

AbstractThe α7 nicotinic acetylcholine receptor (nAChR), a pentameric ligand-gated ion channel, plays important roles in cognition, neuroprotection, and anti-inflammation. As a potential drug target, α7 nAChR has different binding sites for different ligands, particularly agonists and positive allosteric modulators (PAMs). Ago-PAMs can both directly activate and allosterically modulate α7 nAChR. However, the mechanism underlying α7 nAChR modulation by ago-PAM has yet to be fully elucidated.

3 weeks ago | nature.com | Jie-Ying Zhu |Min Chen |Wang-Jing Mu |Hong-Yang Luo |Shan Li |Lin-Jing Yan | +4 more

AbstractExercise combats obesity and metabolic disorders, but the underlying mechanism is incompletely understood. KLF10, a transcription factor involved in various biological processes, has an undefined role in adipose tissue and obesity. Here, we show that exercise facilitates adipocyte-derived KLF10 expression via SIRT1/FOXO1 pathway.

2 months ago | nature.com | Runnan Cao |Cory S Inman |Xin Li |Adam N. Mamelak |Jon Willie

AbstractHow the brain encodes, recognizes, and memorizes general visual objects is a fundamental question in neuroscience. Here, we investigated the neural processes underlying visual object perception and memory by recording from 3173 single neurons in the human amygdala and hippocampus across four experiments. We employed both passive-viewing and recognition memory tasks involving a diverse range of naturalistic object stimuli.

Jan 20, 2025 | nature.com | Xin Li

Abstract“The narrative” is a complex cognitive process that has sparked a debate on whether its features age through maintenance or decline. To address this question, we attempted to uncover the narrative aging and its underlying neural characteristics with a cross-validation based cognitive neuro-decoding statistical framework. This framework used a total of 740 healthy older participants with completed narrative and extensive neuropsychological tests and MRI scans.

Oct 3, 2024 | nature.com | Xin Li

AbstractCircular RNA (circRNA) plays a pivotal role in breast cancer onset and progression. Understanding the biological functions and underlying molecular mechanisms of dysregulated circRNAs in breast cancer is crucial for elucidating its pathogenesis and identifying potential therapeutic targets. In this study, we investigated the role and molecular mechanism of circGSK3β in breast cancer.