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3 weeks ago | 
nature.com | Runnan Cao |Chujun Lin |Emanuela De Falco |Jon Willie |James DiCarlo |Xin Li
AbstractNeurons in the human amygdala and hippocampus are classically thought to encode a person’s identity invariant to visual features. However, it remains largely unknown how visual information from higher visual cortical areas is translated into such a semantic representation of an individual person.
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2 months ago | 
nature.com | Xin Li |Huadong Guo |Guodong Cheng |Youhua Ran |Min Feng |Tao Che | +5 more
AbstractAs important components of global commons, environmental changes in polar regions are crucial to the local and global sustainability. However, they have received little attention in the current framework of sustainable development goals (SDGs). This study examines the impacts of climate change in polar regions, emphasizing the interconnectedness of these areas with other parts of the global system.
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2 months ago | 
nature.com | Xin Li
AbstractDisease relapse is a major cause of treatment failure after allogeneic haematopoietic stem cell transplantation (allo-HSCT) in patients with acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS). We retrospectively evaluated all patients (n = 145) with high-risk AML and MDS who underwent allo-HSCT between 2016 and 2022. Among them, 53 patients received maintenance therapy with azacitidine (AZA), and 10 of these patients received preemptive therapy.
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2 months ago | 
nature.com | Xin Li |Qipeng Yan |Lei Liu
AbstractThe α7 nicotinic acetylcholine receptor (nAChR), a pentameric ligand-gated ion channel, plays important roles in cognition, neuroprotection, and anti-inflammation. As a potential drug target, α7 nAChR has different binding sites for different ligands, particularly agonists and positive allosteric modulators (PAMs). Ago-PAMs can both directly activate and allosterically modulate α7 nAChR. However, the mechanism underlying α7 nAChR modulation by ago-PAM has yet to be fully elucidated.
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2 months ago | 
nature.com | Jie-Ying Zhu |Min Chen |Wang-Jing Mu |Hong-Yang Luo |Shan Li |Lin-Jing Yan | +4 more
AbstractExercise combats obesity and metabolic disorders, but the underlying mechanism is incompletely understood. KLF10, a transcription factor involved in various biological processes, has an undefined role in adipose tissue and obesity. Here, we show that exercise facilitates adipocyte-derived KLF10 expression via SIRT1/FOXO1 pathway.
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Feb 9, 2025 | 
nature.com | Runnan Cao |Cory S Inman |Xin Li |Adam N. Mamelak |Jon Willie
AbstractHow the brain encodes, recognizes, and memorizes general visual objects is a fundamental question in neuroscience. Here, we investigated the neural processes underlying visual object perception and memory by recording from 3173 single neurons in the human amygdala and hippocampus across four experiments. We employed both passive-viewing and recognition memory tasks involving a diverse range of naturalistic object stimuli.
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Jan 20, 2025 | 
nature.com | Xin Li
Abstract“The narrative” is a complex cognitive process that has sparked a debate on whether its features age through maintenance or decline. To address this question, we attempted to uncover the narrative aging and its underlying neural characteristics with a cross-validation based cognitive neuro-decoding statistical framework. This framework used a total of 740 healthy older participants with completed narrative and extensive neuropsychological tests and MRI scans.
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Oct 3, 2024 | 
nature.com | Xin Li
AbstractCircular RNA (circRNA) plays a pivotal role in breast cancer onset and progression. Understanding the biological functions and underlying molecular mechanisms of dysregulated circRNAs in breast cancer is crucial for elucidating its pathogenesis and identifying potential therapeutic targets. In this study, we investigated the role and molecular mechanism of circGSK3β in breast cancer.
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Feb 5, 2024 | 
nature.com | Xin Li |Min Fang |Zihai Li
AbstractThe maturation process of natural killer (NK) cells, which is regulated by multiple transcription factors, determines their functionality, but few checkpoints specifically targeting this process have been thoroughly studied. Here we show that NK-specific deficiency of glucose-regulated protein 94 (gp96) leads to decreased maturation of NK cells in mice.
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Jan 3, 2024 | 
nature.com | Xin Li
Refractory metals and alloys have high melting points and high strength at elevated temperatures. But one of the main challenges for their applications is the lack of room-temperature tensile ductility and fracture toughness. While the introduction of the MPEA concept has largely expanded the design flexibility of the composition and properties of refractory alloys, the tensile ductility is still limited in general.
