Xuejun Qin

Oct 20, 2024 | nature.com | Kyle Sullivan |Matthew Lane |Mirko Pavicic |Xuejun Qin |Niamh Mullins |Anna R. Docherty | +6 more

AbstractGenome-wide association studies (GWAS) identify genetic variants underlying complex traits but are limited by stringent genome-wide significance thresholds. We present GRIN (Gene set Refinement through Interacting Networks), which increases confidence in the expanded gene set by retaining genes strongly connected by biological networks when GWAS thresholds are relaxed. GRIN was validated on both simulated interrelated gene sets as well as multiple GWAS traits.