Niamh Mullins

Oct 20, 2024 | nature.com | Kyle Sullivan |Matthew Lane |Mirko Pavicic |Xuejun Qin |Niamh Mullins |Anna R. Docherty | +6 more

AbstractGenome-wide association studies (GWAS) identify genetic variants underlying complex traits but are limited by stringent genome-wide significance thresholds. We present GRIN (Gene set Refinement through Interacting Networks), which increases confidence in the expanded gene set by retaining genes strongly connected by biological networks when GWAS thresholds are relaxed. GRIN was validated on both simulated interrelated gene sets as well as multiple GWAS traits.

Jul 30, 2024 | digitalcommons.library.tmc.edu | Enda M. Byrne |Anna R. Docherty |Niamh Mullins |Allison Ashley-Koch

OBJECTIVE: Suicidal behavior is heritable and is a major cause of death worldwide. Two large-scale genome-wide association studies (GWASs) recently discovered and cross-validated genome-wide significant (GWS) loci for suicide attempt (SA). The present study leveraged the genetic cohorts from both studies to conduct the largest GWAS meta-analysis of SA to date.

Oct 1, 2023 | ajp.psychiatryonline.org | Enda M. Byrne |Anna R. Docherty |Niamh Mullins |Allison Ashley-Koch

Suicide accounted for more than 700,000 deaths worldwide in 2019 and was the fourth leading cause of death among 15- to 29-year-olds (1). Suicide attempt is even more common (2–4). Suicide attempt is strongly associated with psychiatric conditions, poor quality of life, traumatic experiences, and social and economic burden (1) and is the single strongest predictor of future suicide death (5).