Xueyi Shen

May 17, 2024 | nature.com | Rosie Walker |Nicolas Perrot |Marie Pigeyre |Danni A Gadd |Aleks Stolicyn |Archie Campbell | +8 more

AbstractDecline in cognitive function is the most feared aspect of ageing. Poorer midlife cognitive function is associated with increased dementia and stroke risk. The mechanisms underlying variation in cognitive function are uncertain. Here, we assessed associations between 1160 proteins’ plasma levels and two measures of cognitive function, the digit symbol substitution test (DSST) and the Montreal Cognitive Assessment in 1198 PURE-MIND participants.

Apr 10, 2023 | biologicalpsychiatryjournal.com | Yara J. Toenders |Xueyi Shen |Yuri Milaneschi |Laura Han

Two independent mega-analyses across a total of 32 cohorts and >3,400 patients and >2,800 controls worldwide revealed that persons with major depressive disorder (MDD) show older appearing brains compared to non-depressed peers. However, the biological mechanisms underlying the age-related structural brain alterations remain unknown. Here, we examined whether variations in the “brain age gap” were linked to variations in polygenic risk for several depression-related traits.