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Nov 5, 2024 | 
nature.com | Tanya J. Major |Riku Takei |Yuya Shirai |Wei Qing Wang |Murray Cadzow |Amanda Phipps-Green | +35 more
Correction to: Nature Genetics https://doi.org/10.1038/s41588-024-01921-5. Published online 15 October 2024. In the version of the article originally published, there were errors in the consortium lists at the end of the paper. Maureen Rischmueller, Hyon K. Choi, Masahiro Nakatochi, Jeff N. Miner, Daniel H. Solomon, Kathleen M. Giacomini and Deanna J. Brackman were erroneously listed as members of the Japan Gout Genomics Consortium.
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Oct 15, 2024 | 
nature.com | Tanya J. Major |Riku Takei |Yuya Shirai |Wei Qing Wang |Murray Cadzow |Amanda Phipps-Green | +35 more
AbstractGout is a chronic disease that is caused by an innate immune response to deposited monosodium urate crystals in the setting of hyperuricemia. Here, we provide insights into the molecular mechanism of the poorly understood inflammatory component of gout from a genome-wide association study (GWAS) of 2.6 million people, including 120,295 people with prevalent gout. We detected 377 loci and 410 genetically independent signals (149 previously unreported loci in urate and gout).
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Oct 7, 2024 | 
nature.com | Julia Sidorenko |Kathryn E Kemper |Bjørn Olav Åsvold |Alireza Ani |Rujia Wang |Ilja M. Nolte | +13 more
AbstractLinkage studies have successfully mapped loci underlying monogenic disorders, but mostly failed when applied to common diseases. Conversely, genome-wide association studies (GWASs) have identified replicable associations between thousands of SNPs and complex traits, yet capture less than half of the total heritability.
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Sep 26, 2024 | 
nature.com | Mary Barker |Kadri Koiv |Ingibjörg Magnúsdóttir |Hannah Milbourn |Bin Wang |Gillian Murphy | +15 more
AbstractIndividuals with mental illness are at higher risk of severe COVID-19 outcomes. However, previous studies on the uptake of COVID-19 vaccination in this population have reported conflicting results.
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Jul 25, 2024 | 
lexology.com | Archie Campbell |Jonathan Cripps |Georgina Shenton
Decarbonisation and the drive to net zero affects every person and every business. Our cross-practice international team of lawyers at Stephenson Harwood can help you both navigate through these challenges and help your business make the most of the opportunities no matter where you are on your journey. Part of the journey is understanding the constantly evolving jargon that often surrounds the topic of climate change and decarbonisation.
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May 17, 2024 | 
nature.com | Rosie Walker |Nicolas Perrot |Marie Pigeyre |Danni A Gadd |Aleks Stolicyn |Archie Campbell | +8 more
AbstractDecline in cognitive function is the most feared aspect of ageing. Poorer midlife cognitive function is associated with increased dementia and stroke risk. The mechanisms underlying variation in cognitive function are uncertain. Here, we assessed associations between 1160 proteins’ plasma levels and two measures of cognitive function, the digit symbol substitution test (DSST) and the Montreal Cognitive Assessment in 1198 PURE-MIND participants.
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Feb 29, 2024 | 
lexology.com | Archie Campbell
Click here to listen to the audio. This episode we're joined by David Dahan of Auditel to discuss the help available to companies wanting to reduce their carbon footprint, the difference between carbon neutral and net zero and the different carbon certifications in play. David-Alexandre Dahan, BA MBA FCMASenior Advisor at AuditelDavid is a strategic advisor, who helps organisations on ESG, sustainability and their carbon reduction journey towards long term net-zero objectives.
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Feb 15, 2024 | 
medrxiv.org | Yipeng Cheng |Christian Gieger |Archie Campbell |Andrew McIntosh |Andrew Mcintosh
R.E.M is an advisor to the Epigenetic Clock Development Foundation and Optima Partners. All other authors declare no competing interests. This research was funded in whole, or in part, by the Wellcome Trust [104036/Z/14/Z, 108890/Z/15/Z, 216767/Z/19/Z]. For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission.
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Jan 31, 2024 | 
lexology.com | Catriona Berman |Simon Brading |Archie Campbell |Alexander Chadwick |Paul Hayward-Surry |Stephen Laud | +4 more
The scenarioYou're an estate manager. You manage a number of different types of property including retail parks and some high profile central London offices. The occupier of your main office building is a large financial institution which has provided finance to a major oil company. You've had a number of issues with trespassers over the years.
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Oct 16, 2023 | 
lexology.com | Archie Campbell |Navpreet Atwal |James Styles |Sean Crowley |Charlotte Drake
IntroductionThe Building Safety Act 2022 ("BSA 2022") has been described as "the biggest change in building safety in a generation"1. The changes introduced by BSA 2022 were prompted by the recommendations of Dame Judith Hackitt in the independent review of building regulations and fire safety which was commissioned following the Grenfell Tower fire in 2017.
