Yutao Liu

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Microbiota-derived succinate promotes enterohaemorrhagic Escherichia coli virulence via lysine succinylation - Nature Microbiology

2 months ago | nature.com | Yutao Liu |Lu Feng |Di Huang |Kai Zhang |Lei Wang

AbstractSuccinate upregulates enterohaemorrhagic Escherichia coli (EHEC) virulence. Lysine succinylation, a post-translational modification, regulates cellular function in eukaryotes but is less characterized in bacteria. We hypothesized that lysine succinylation regulates EHEC virulence. Here we used SILAC-based proteomics and characterized the EHEC succinylome to show that the transcription factor, PurR, is succinylated at K24 and K55.

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