Lu Feng

2 months ago | nature.com | Yutao Liu |Lu Feng |Di Huang |Kai Zhang |Lei Wang

AbstractSuccinate upregulates enterohaemorrhagic Escherichia coli (EHEC) virulence. Lysine succinylation, a post-translational modification, regulates cellular function in eukaryotes but is less characterized in bacteria. We hypothesized that lysine succinylation regulates EHEC virulence. Here we used SILAC-based proteomics and characterized the EHEC succinylome to show that the transcription factor, PurR, is succinylated at K24 and K55.

Nov 17, 2024 | nature.com | Lu Feng

AbstractIschemic stroke poses a significant global health risk. Currently, recanalization of blood flow through surgery or medication is the only effective means to control ischemia-reperfusion injury. This study aims to explore the role and molecular mechanism of OGT in regulating neuronal injury and motor deficits following a stroke. The MCAO and OGD/R models were established to validate the therapeutic efficacy of OGT in mitigating neuronal injury and motor dysfunction following stroke.

Oct 14, 2024 | dialnet.unirioja.es | Lu Feng

Ayuda Buscar en la ayuda Buscar en la ayuda La traducción de los nombres de los platos chinos al español desde la perspectiva de la traducción semántica y la comunicativa Lu Feng [1] [1] Universidad de Academia de Ciencia Sociales de China Localización: Orkopata: Revista de Lingüística, Literatura y Arte, ISSN-e 2955-8263, Vol. 3, Nº. 3, 2024, págs.

Mar 27, 2024 | elifesciences.org | Hong Long Chen |Lijun Sun |Lu Feng |Xue Han

eLife assessment This study provides valuable findings showing the production of IL-22 from intestinal ILC3 during intermittent fasting promotes beigeing of white adipose tissue. The authors provided solid data and mechanistic insight by which IL-22-derived from ILC3 directly induces beigeing.

Feb 23, 2024 | biorxiv.org | Hong Long Chen |Lijun Sun |Lu Feng |Xue Han

AbstractMechanism underlying the metabolic benefit of intermittent fasting remains largely unknown. Here, we reported that intermittent fasting promoted IL-22 production by type 3 innate lymphoid cells (ILC3s) and subsequent beigeing of subcutaneous white adipose tissue. Adoptive transfer of intestinal ILC3s increased beigeing of white adipose tissue in diet-induced-obese mice. Exogenous IL-22 significantly increased the beigeing of subcutaneous white adipose tissue.