Zbigniew K. Wszolek

Jun 5, 2024 | nature.com | Barbara Schormair |Steven Bell |Maria Didriksen |Ambra Stefani |Georgios M. Hadjigeorgiou |Owen A Ross | +16 more

AbstractRestless legs syndrome (RLS) affects up to 10% of older adults. Their healthcare is impeded by delayed diagnosis and insufficient treatment. To advance disease prediction and find new entry points for therapy, we performed meta-analyses of genome-wide association studies in 116,647 individuals with RLS (cases) and 1,546,466 controls of European ancestry. The pooled analysis increased the number of risk loci eightfold to 164, including three on chromosome X.

Jan 7, 2024 | nature.com | Dhairya A. Lakhani |Vishal Patel |Chen Lin |Sina Straub |Zbigniew K. Wszolek |Philip W. Tipton

AbstractParkinson’s disease (PD) is a prevalent neurodegenerative disorder that presents a diagnostic challenge due to symptom overlap with other disorders. Neuromelanin (NM) imaging is a promising biomarker for PD, but adoption has been limited, in part due to subpar performance at standard MRI field strengths.