Zhuo Huang

Jun 27, 2024 | nature.com | Pengliang Chi |Xiang Wang |Jialu Li |Yuqi Zhang |Lu Chen |Ruobing Ren | +2 more

Dear Editor, The proton-activated chloride (PAC) channel (also known as acid-sensitive outwardly rectifying anion channel, ASOR) plays critical roles in acid-induced cell death and endocytosis.1,2 The structural investigations revealed that three protomers construct one PAC channel.3,4,5 PAC’s three captured states (resting, activated, and desensitized) uncovered the gating and proton-sensing mechanism.3,4,5 However, little is known about the regulatory factors of PAC.6 This is a preview of...

Jan 30, 2024 | pericles.pericles-prod.literatumonline.com | Lei Zhang |Zhuo Huang |Xiao Chen |Yi Zheng

Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202314110-sup-0001-SuppMat.pdf868.3 KB Supporting Information References 1, , Nat. Mater. 2012, 11, 917. 2, , , , , , , Science 2013, 339, 310. 3, , , , , , Science 2014, 343, 160. 4, , , , , , , Science 2011, 334, 333. 5, , , , , Phys. Rep. 2016, 634, 1. 6, , , , Nat. Photon. 2023, 17, 48. 7, , , , , Light: Sci. Appl. 2014, 3, e218. 8, , , , Sci. Rep.

Jan 30, 2024 | onlinelibrary.wiley.com | Lei Zhang |Zhuo Huang |Xiao Chen |Yi Zheng

Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202314110-sup-0001-SuppMat.pdf868.3 KB Supporting Information References 1, , Nat. Mater. 2012, 11, 917. 2, , , , , , , Science 2013, 339, 310. 3, , , , , , Science 2014, 343, 160. 4, , , , , , , Science 2011, 334, 333. 5, , , , , Phys. Rep. 2016, 634, 1. 6, , , , Nat. Photon. 2023, 17, 48. 7, , , , , Light: Sci. Appl. 2014, 3, e218. 8, , , , Sci. Rep.

May 10, 2023 | lexology.com | Zhipeng Yang |Zhuo Huang

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Feb 23, 2023 | nature.com | YUE LI |Bo Huang |Yan Zhao |Zhuo Huang

AbstractThe sodium channel NaV1.6 is widely expressed in neurons of the central and peripheral nervous systems, which plays a critical role in regulating neuronal excitability. Dysfunction of NaV1.6 has been linked to epileptic encephalopathy, intellectual disability and movement disorders.