Zilong Zhang

Apr 18, 2024 | mdpi.com | Yuliang Wang |Feifei Li |Dan Liu |Zilong Zhang

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Jan 16, 2024 | cell.com | Zilong Zhang |Sun Yat-sen |Xu Xu |Di Zhang

The roles of platelets/megakaryocytes (MKs), the key components in the blood system, in the tumor microenvironment and antitumor immunity are unclear. In patients with colorectal cancer, the number of platelets was significantly increased in patients with metastasis, and Erbin expression was highly expressed in platelets from patients with metastases. Moreover, Erbin knockout in platelets/MKs suppressed lung metastasis in mice and promoted aggregations of platelets.