Aging

Aging publishes scientific articles covering a wide range of topics in aging research. This includes studies on organismal aging and cellular senescence, the repair of DNA damage, the genetic factors influencing aging in organisms from yeast to mammals, the mechanisms that regulate longevity, and the prevention and treatment of age-related conditions like cancer and Alzheimer’s disease. The journal also explores anti-aging strategies, drug development, and the significance of signaling pathways such as mTOR in the aging process, along with potential methods to influence these pathways to extend lifespan. The goal of the journal is to advance the treatment of age-related diseases by slowing the aging process, to validate anti-aging medications through their effects on age-related illnesses, to prevent cancer by targeting aging, and to examine the impact of COVID-19 as a condition that varies with age.

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Sleep Deprivation in Dementia: Heart Disease, Diabetes, Anxiety, and Thyroid Disorders | Aging

Dec 2, 2024 | aging-us.com

"Sleep disturbances are a significant concern in individuals with dementia, affecting their overall health and quality of life, as well as that of their family members and caregivers."Listen to an aud...
LncRNA DANCR suppresses acute myocardial infarction in mice via mediating p-RXRA/TRAF2/NIK/IKK/NF-κB signaling pathway

Nov 14, 2024 | aging-us.com | Li Zhao |Zhi Li

Objectives: This study aimed to investigate the role of LncRNA differentiation antagonizing non-protein coding RNA (DANCR) in acute myocardial infarction (AMI). Methods: A mouse model of AMI was established, and the cardiac contractile function was detected. Next, cardiomyocytes treated with oxygen-glucose deprivation (OGD) were used for gain- and loss-function experiments in vitro.
Lymph node metastasis determined miRNAs in esophageal squamous cell carcinoma

Oct 14, 2024 | aging-us.com | Feng Wei |Shufeng Bi |Mengmeng Li |Jia Yu

Purpose: There is no golden noninvasive and effective technique to diagnose lymph node metastasis (LNM) for esophageal squamous cell carcinoma (ESCC) patients. Here, a classifier was proposed consisting of miRNAs to screen ESCC patients with LNM from the ones without LNM. Methods: miRNA expression and clinical data files of 93 ESCC samples were downloaded from TCGA as the discovery set and 119 ESCC samples with similar dataset GSE43732 as the validation set.
DNA methylation-driven gene FAM3D promotes colorectal cancer growth via the ATF4-SESN2-mTORC1 pathway

Oct 10, 2024 | aging-us.com | Ting Zheng |Ding Zhang |Mingxue Wang |Qingzhen Fu

Research Paper Volume 16, Issue 19 pp 12866—12892 1 Department of Epidemiology, Public Health School of Harbin Medical University, Harbin, Heilongjiang, P.R. China https://doi.org/10.18632/aging.206115 How to Cite Cite this Article Select the format you require from the list below Click to copy this citation from the text box above or download the citation: Citation | Copyright: © 2024 Zheng et al.
DNA methylation-driven gene FAM3D promotes colorectal cancer growth via the ATF4-SESN2-mTORC1 pathway

Oct 10, 2024 | aging-us.com | Ting Zheng |Ding Zhang |Qingzhen Fu |Mingxue Wang

Research Paper Volume 16, Issue 19 pp 12866—12892 1 Department of Epidemiology, Public Health School of Harbin Medical University, Harbin, Heilongjiang, P.R. China https://doi.org/10.18632/aging.206115 How to Cite Cite this Article Select the format you require from the list below Click to copy this citation from the text box above or download the citation: Citation | Copyright: © 2024 Zheng et al.
Longitudinal activity monitoring and lifespan: quantifying the interface

Sep 9, 2024 | aging-us.com | Su I Iao |Poorbita Kundu |Han Chen |James Carey

Research Perspective Volume 16, Issue 17 pp 12108—12122 1 Department of Statistics, University of California, Davis, CA 95616, USA 2 Department of Entomology, University of California, Davis, CA 95616, USA * Equal contribution https://doi.org/10.18632/aging.206106 How to Cite Cite this Article Select the format you require from the list below Click to copy this citation from the text box above or download the citation: Citation | Copyright: © 2024 Iao et al. This is an open access article...
Longitudinal activity monitoring and lifespan: quantifying the interface

Sep 9, 2024 | aging-us.com | Su I Iao |Poorbita Kundu |Han Chen |James Carey

Research Perspective Volume 16, Issue 17 pp 12108—12122 1 Department of Statistics, University of California, Davis, CA 95616, USA 2 Department of Entomology, University of California, Davis, CA 95616, USA * Equal contribution https://doi.org/10.18632/aging.206106 How to Cite Cite this Article Select the format you require from the list below Click to copy this citation from the text box above or download the citation: Citation | This is an open access article distributed under the terms of...
UBR1 is a prognostic biomarker and therapeutic target associated with immune cell infiltration in gastric cancer

Aug 23, 2024 | aging-us.com | Weiwei Yuan |Jianye Han |CHEN CHEN |Yue Qiu

Background: Ubiquitination is a targeted protein modification process mediated by intracellular molecules. UBR1 encodes a protein that binds to unstable N-terminal residues of substrate proteins and contributes to the formation of substrate-linked polyubiquitin chains. However, the function and cellular pathways of UBR1 in tumors have received inadequate attention.
UBR1 is a prognostic biomarker and therapeutic target associated with immune cell infiltration in gastric cancer

Aug 23, 2024 | aging-us.com | Weiwei Yuan |Jianye Han |CHEN CHEN |Yue Qiu

Research Paper Volume 16, Issue 16 pp 12029—12049 1 Department of Thyroid Surgery, Baoshan Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201999, China 2 Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Anhui Public Health Clinical Center, Hefei 230012, China 3 Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China * Equal contribution...
Notch1 signaling pathway promotes growth and metastasis of gastric cancer via modulating CDH5

Aug 21, 2024 | aging-us.com | Lingshan Zhou |Yuan Yang |yuwei Ye |Qian Qiao

Research Paper Volume 16, Issue 16 pp 11893—11903 1 Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou 730000, China 2 Department of Geriatrics Ward 2, The First Hospital of Lanzhou University, Lanzhou 730000, China 3 Department of Gastroenterology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China 4 Department of Gastroenterology Ward 2, Shanxi Provincial People’s Hospital, Xian 710000, China 5 The...