PNAS

About PNAS The Proceedings of the National Academy of Sciences (PNAS) is a highly respected and frequently cited scientific journal that publishes over 3,300 research papers each year. It serves as the official journal of the National Academy of Sciences (NAS) and features a wide range of impactful original research across the biological, physical, and social sciences. Researchers from around the globe can submit their work, as the journal is open to all scientists regardless of their location. Founded in 1914 to celebrate the 50th anniversary of the NAS, PNAS has consistently aimed to publish top-notch scientific studies while ensuring that these findings are accessible to a wide audience. Besides original research articles, PNAS also features science news, commentaries, perspectives, colloquium papers, podcasts, and profiles of NAS members. In 1995, PNAS began accepting submissions directly from researchers who are not affiliated with the NAS. Although we maintain a close relationship with the NAS, which oversees a strict three-tier peer review process, we now receive over 17,000 direct submissions annually, making up more than 75% of our published content. PNAS operates on a subscription basis, but all articles become freely available after six months. Additionally, authors can opt for open access, allowing their work to be available at no cost to readers right away. PNAS also provides free access to its content for researchers in developing countries.

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Articles

Psychological impacts of climate change on US youth

4 weeks ago | pnas.org | Adam Green |Gary M. Feinman |Pablo Cruz

Climate Psychology Alliance, The Handbook of Climate Psychology (Climate Psychology Alliance, 2020). S. Clayton, C. M. Manning, K. Krygsman, M. Speiser, Mental Health and Our Changing Climate: Impacts, Implications, and Guidance (American Psychological Association, and ecoAmerica, Washington, D.C., 2017). P. Pihkala, Anxiety and the ecological crisis: An analysis of eco-anxiety and climate anxiety. Sustainability 12, 7836 (2020). F. Vergunst, H. L.
Protein Phosphatase 1 Regulatory Subunit 3C integrates cholesterol metabolism and isocitrate dehydrogenase in chondrocytes and neoplasia

1 month ago | pnas.org | Adam Green |Gary M. Feinman |Pablo Cruz

Materials and MethodsAll animals were used according to the approved protocol by the Institutional Animal Care and Use Committee at Duke University. Mice used in this study include Ppp1r3cfl/fl mice (32), overexpressing Ppp1r3c (Ppp1r3cOE) mice (46), Scapfl/fl mice (JAX:004162) (2, 47), Idh1R132Q-KI (Idh1LSL/+) mice (20), R26IDH1R132C mice, R26IDH2R172S mice, Col2a1Cre mice (JAX:003554) (48), Col2a1Cre/ERT2 mice (29, 49), and interleukin-2 receptor gamma chain (gamma)-null NOD/SCID (NSG) mice.
Molecular design of a therapeutic LSD analogue with reduced hallucinogenic potential

1 month ago | pnas.org | Jeremy R. Tuck |Lee Dunlap |Cassandra J. Hatzipantelis |Yara A. Khatib

Molecular design of a therapeutic LSD analogue with reduced hallucinogenic potentialJeremy R. Tuck https://orcid.org/0000-0002-8807-3014, Lee E. Dunlap, Yara A. Khatib https://orcid.org/0000-0002-8342-7100, +26 , Cassandra J. Hatzipantelis https://orcid.org/0000-0001-5376-7887, Sammy Weiser Novak, Rachel M. Rahn, Alexis R. Davis, Adam Mosswood https://orcid.org/0009-0008-3842-557X, Anna M. M. Vernier https://orcid.org/0000-0001-7226-4417, Ethan M. Fenton https://orcid.org/0009-0008-1945-7517, Isak K.
Age-dependent cytokine surge in blood precedes cancer diagnosis

1 month ago | pnas.org | Guangbo Chen |Mark Davis |Saima Malik-Moraleda |Maya Taliaferro

P. Brodin et al., Variation in the human immune system is largely driven by non-heritable influences. Cell 160, 37–47 (2015). C. Franceschi, P. Garagnani, P. Parini, C. Giuliani, A. Santoro, Inflammaging: A new immune–metabolic viewpoint for age-related diseases. Nat. Rev. Endocrinol. 14, 576–590 (2018). C. Franceschi, J. Campisi, Chronic inflammation (Inflammaging) and its potential contribution to age-associated diseases. J. Gerontol.: Series A 69, S4–S9 (2014). N. Ouchi, J. L. Parker, J. J. Lugus, K.
Structures and functions of the limited natural polyclonal antibody response to parvovirus infection

Feb 14, 2025 | pnas.org | Colin R. Parrish |Dorian Leger |Fardin Ghaffari-Tabrizi |Matthew Shaw

N. L. Miller, R. Raman, T. Clark, R. Sasisekharan, Complexity of viral epitope surfaces as evasive targets for vaccines and therapeutic antibodies. Front. Immunol. 13, 904609 (2022). A. Nourmohammad, J. Otwinowski, J. B. Plotkin, Host-pathogen coevolution and the emergence of broadly neutralizing antibodies in chronic infections. PLoS Genet. 12, e1006171 (2016). R. A. López-Astacio, O. F. Adu, H. Lee, S. L. Hafenstein, C. R.
Protein crosstalk complicates cell signaling studies—but can be fixed | Journal Club | PNAS

Jan 31, 2025 | pnas.org

Reporter probes meant to track cell activity might not be as accurate as once thought. Here, melanoma cells express the extracellular signal-regulated kinase (ERK) translocation reporter. Image credit: Timothy Hoffman
Behavioral nudges prevent loan delinquencies at scale: A 13-million-person field experiment

Jan 23, 2025 | pnas.org | Robert Kuan |Kristin Blagg |Benjamin Castleman |Katherine L. Milkman

Behavioral nudges prevent loan delinquencies at scale: A 13-million-person field experimentEdited by Susan Dynarski, Harvard University, Cambridge, MA; received August 16, 2024; accepted December 3, 2024 by Editorial Board Member Orley C. AshenfelterSignificanceWith rising levels of student loan debt, finding strategies to help students repay their loans has become a critical policy challenge.
Genetic structure in village dogs reveals a Central Asian domestication origin

Jan 15, 2025 | pnas.org | Laura Shannon |Ryan Boyko |Marta G. Castelhano |Elizabeth Corey

Genetic structure in village dogs reveals a Central Asian domestication originLaura M. Shannon, Ryan H. Boyko, Marta Castelhano, +23 , Elizabeth Corey, Jessica J. Hayward, Corin McLean, Michelle E. White, Mounir Abi Said, Baddley A. Anita, Nono Ikombe Bondjengo, Jorge Calero, Ana Galov, Marius Hedimbi, Bulu Imam, Rajashree Khalap, Douglas Lally, Andrew Masta, Kyle C. Oliveira, Lucía Pérez, Julia Randall, Nguyen Minh Tam, Francisco J. Trujillo-Cornejo, Carlos Valeriano, Nathan B. Sutter, Rory J.
In This Issue | PNAS

Jan 14, 2025 | pnas.org | Carter Smith |Elizabeth A. DeMattia |Elizabeth L Albright |Abigail Bromberger

ContentsAGRICULTURAL SCIENCESEARTH, ATMOSPHERIC, AND PLANETARY SCIENCESEARTH, ATMOSPHERIC, AND PLANETARY SCIENCESEARTH, ATMOSPHERIC, AND PLANETARY SCIENCESEARTH, ATMOSPHERIC, AND PLANETARY SCIENCESENVIRONMENTAL SCIENCESPHYSIOLOGYEARTH, ATMOSPHERIC, AND PLANETARY SCIENCESECOLOGYA simple technique ties polymers in knotsAGRICULTURAL SCIENCESHarlequin ladybird feeding on the eggs of a seven-spotted ladybird.
Microbes could convert industrial wastewater into ecofriendly products

Jan 8, 2025 | pnas.org | Carter Smith |Elizabeth A. DeMattia |Elizabeth L Albright |Abigail Bromberger

Every year, US dairy producers churn out billions of pounds of cheese—over 14 billion in 2023 alone. As that cheese heads to market, producers must contend with what’s left behind: roughly 6 billion pounds of whey by dry weight, says Declan Roche, chief commercial officer of Foremost Farms USA, a Wisconsin-based dairy cooperative. Making cheese entails separating out the curd, as seen here, and leaving behind a lot of whey.