PNAS

About PNAS The Proceedings of the National Academy of Sciences (PNAS) is a highly respected and frequently cited scientific journal that publishes over 3,300 research papers each year. It serves as the official journal of the National Academy of Sciences (NAS) and features a wide range of impactful original research across the biological, physical, and social sciences. Researchers from around the globe can submit their work, as the journal is open to all scientists regardless of their location. Founded in 1914 to celebrate the 50th anniversary of the NAS, PNAS has consistently aimed to publish top-notch scientific studies while ensuring that these findings are accessible to a wide audience. Besides original research articles, PNAS also features science news, commentaries, perspectives, colloquium papers, podcasts, and profiles of NAS members. In 1995, PNAS began accepting submissions directly from researchers who are not affiliated with the NAS. Although we maintain a close relationship with the NAS, which oversees a strict three-tier peer review process, we now receive over 17,000 direct submissions annually, making up more than 75% of our published content. PNAS operates on a subscription basis, but all articles become freely available after six months. Additionally, authors can opt for open access, allowing their work to be available at no cost to readers right away. PNAS also provides free access to its content for researchers in developing countries.

National

English

Journal

Outlet metrics

Domain Authority

Ranking

Global

#28019

United States

#13699

Science and Education/Science and Education

#45

Traffic sources

Monthly visitors

Articles

Protein Phosphatase 1 Regulatory Subunit 3C integrates cholesterol metabolism and isocitrate dehydrogenase in chondrocytes and neoplasia

1 week ago | pnas.org | Adam Green |Gary M. Feinman |Pablo Cruz

Materials and MethodsAll animals were used according to the approved protocol by the Institutional Animal Care and Use Committee at Duke University. Mice used in this study include Ppp1r3cfl/fl mice (32), overexpressing Ppp1r3c (Ppp1r3cOE) mice (46), Scapfl/fl mice (JAX:004162) (2, 47), Idh1R132Q-KI (Idh1LSL/+) mice (20), R26IDH1R132C mice, R26IDH2R172S mice, Col2a1Cre mice (JAX:003554) (48), Col2a1Cre/ERT2 mice (29, 49), and interleukin-2 receptor gamma chain (gamma)-null NOD/SCID (NSG) mice.
Age-dependent cytokine surge in blood precedes cancer diagnosis

1 month ago | pnas.org | Guangbo Chen |Mark Davis |Saima Malik-Moraleda |Maya Taliaferro

P. Brodin et al., Variation in the human immune system is largely driven by non-heritable influences. Cell 160, 37–47 (2015). C. Franceschi, P. Garagnani, P. Parini, C. Giuliani, A. Santoro, Inflammaging: A new immune–metabolic viewpoint for age-related diseases. Nat. Rev. Endocrinol. 14, 576–590 (2018). C. Franceschi, J. Campisi, Chronic inflammation (Inflammaging) and its potential contribution to age-associated diseases. J. Gerontol.: Series A 69, S4–S9 (2014). N. Ouchi, J. L. Parker, J. J. Lugus, K.
Protein crosstalk complicates cell signaling studies—but can be fixed | Journal Club | PNAS

2 months ago | pnas.org

Reporter probes meant to track cell activity might not be as accurate as once thought. Here, melanoma cells express the extracellular signal-regulated kinase (ERK) translocation reporter. Image credit: Timothy Hoffman
Behavioral nudges prevent loan delinquencies at scale: A 13-million-person field experiment

Jan 23, 2025 | pnas.org | Robert Kuan |Kristin Blagg |Benjamin Castleman |Katherine L. Milkman

Behavioral nudges prevent loan delinquencies at scale: A 13-million-person field experimentEdited by Susan Dynarski, Harvard University, Cambridge, MA; received August 16, 2024; accepted December 3, 2024 by Editorial Board Member Orley C. AshenfelterSignificanceWith rising levels of student loan debt, finding strategies to help students repay their loans has become a critical policy challenge.
Genetic structure in village dogs reveals a Central Asian domestication origin

Jan 15, 2025 | pnas.org | Laura Shannon |Ryan Boyko |Marta G. Castelhano |Elizabeth Corey

Genetic structure in village dogs reveals a Central Asian domestication originLaura M. Shannon, Ryan H. Boyko, Marta Castelhano, +23 , Elizabeth Corey, Jessica J. Hayward, Corin McLean, Michelle E. White, Mounir Abi Said, Baddley A. Anita, Nono Ikombe Bondjengo, Jorge Calero, Ana Galov, Marius Hedimbi, Bulu Imam, Rajashree Khalap, Douglas Lally, Andrew Masta, Kyle C. Oliveira, Lucía Pérez, Julia Randall, Nguyen Minh Tam, Francisco J. Trujillo-Cornejo, Carlos Valeriano, Nathan B. Sutter, Rory J.
In This Issue | PNAS

Jan 14, 2025 | pnas.org | Carter Smith |Elizabeth A. DeMattia |Elizabeth L Albright |Abigail Bromberger

ContentsAGRICULTURAL SCIENCESEARTH, ATMOSPHERIC, AND PLANETARY SCIENCESEARTH, ATMOSPHERIC, AND PLANETARY SCIENCESEARTH, ATMOSPHERIC, AND PLANETARY SCIENCESEARTH, ATMOSPHERIC, AND PLANETARY SCIENCESENVIRONMENTAL SCIENCESPHYSIOLOGYEARTH, ATMOSPHERIC, AND PLANETARY SCIENCESECOLOGYA simple technique ties polymers in knotsAGRICULTURAL SCIENCESHarlequin ladybird feeding on the eggs of a seven-spotted ladybird.
Microbes could convert industrial wastewater into ecofriendly products

Jan 8, 2025 | pnas.org | Carter Smith |Elizabeth A. DeMattia |Elizabeth L Albright |Abigail Bromberger

Every year, US dairy producers churn out billions of pounds of cheese—over 14 billion in 2023 alone. As that cheese heads to market, producers must contend with what’s left behind: roughly 6 billion pounds of whey by dry weight, says Declan Roche, chief commercial officer of Foremost Farms USA, a Wisconsin-based dairy cooperative. Making cheese entails separating out the curd, as seen here, and leaving behind a lot of whey.
Escalation of genome defense capacity enables control of an expanding meiotic driver

Jan 7, 2025 | pnas.org | Carter Smith |Elizabeth A. DeMattia |Elizabeth A. Albright |Yuh Chwen G

R. Dawkins, The Selfish Gene (Oxford University Press, 1976). J. H. Werren, Selfish genetic elements, genetic conflict, and evolutionary innovation. Proc. Natl. Acad. Sci. U.S.A. 108, 10863–10870 (2011). B. Czech et al., piRNA-Guided genome defense: From biogenesis to silencing. Annu. Rev. Genet. 52, 131–157 (2018). M. Bruno, M. Mahgoub, T. S. Macfarlan, The arms race between KRAB-zinc finger proteins and endogenous retroelements and its impact on mammals. Annu. Rev. Genet. 53, 393–416 (2019). M. C. Siomi, K. Sato, D.
The magnitude of legal wildlife trade and implications for species survival

Jan 7, 2025 | pnas.org | Michael Marshall |Carter Smith |Elizabeth A. DeMattia |Thomas Strine

The magnitude of legal wildlife trade and implications for species survivalBenjamin Michael Marshall https://orcid.org/0000-0001-9554-0605, Aubrey L. Alamshah https://orcid.org/0009-0006-8955-9952, Pedro Cardoso, +14 , Phillip Cassey, Sebastian Chekunov https://orcid.org/0000-0003-4085-5786, Evan A. Eskew https://orcid.org/0000-0002-1153-5356, Caroline S. Fukushima, Pablo García-Díaz https://orcid.org/0000-0001-5402-0611, Meredith L. Gore https://orcid.org/0000-0002-2613-4715, Julie L.
Individualized temporal patterns drive human sleep spindle timing

Jan 7, 2025 | pnas.org | Carter Smith |Elizabeth A. DeMattia |Elizabeth A. Albright |Abigail Bromberger

Individualized temporal patterns drive human sleep spindle timingEdited by Emmanuel Mignot, Stanford University School of Medicine, Palo Alto, CA; received March 15, 2024; accepted November 15, 2024SignificanceSleep spindles are cortical electrical waveforms observed during sleep, considered critical for memory consolidation and sleep stability. Abnormalities in sleep spindles have been found in neuropsychiatric disorders and aging and are believed to contribute to functional deficits.