The Journal of Biological Chemistry

The Journal of Biological Chemistry is a scientific journal that publishes peer-reviewed research on a weekly basis. It was founded in 1905 and has been published by the American Society for Biochemistry and Molecular Biology since 1925. This journal focuses on studies related to biochemistry and molecular biology. The current editors-in-chief are Martha Fedor and Herbert Tabor. Articles become freely accessible to the public one year after their publication, and those that are accepted for publication can be accessed for free right away on the journal's website.

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Live Cell Analysis of Mobility and Decay Kinetics of the Histone Variant H3.3

2 weeks ago | jbc.org | Vishal Nehru |David Ball |Abhishek Mukherjee |Daisuke Kurotaki

Research ArticleArticles in Press108557Open access 1Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA 2Section on Neural Developmental Dynamics, Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA 3CCR/LRBGE Optical Microscopy Core, National Cancer...
Nuclear Protein FNBP4: A Novel Inhibitor of Non-diaphanous Formin FMN1-Mediated Actin Cytoskeleton Dynamics

2 weeks ago | jbc.org | Shubham Das |Saikat Das |Amrita Maity |Sankar Maiti

Research ArticleArticles in Press108550Open accessDepartment of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, West Bengal, IndiaPublication History:Received January 9, 2025; Revised April 7, 2025; Accepted April 11, 2025; Published online April 30, 2025DOI: 10.1016/j.jbc.2025.108550 External LinkAlso available on ScienceDirect External LinkCopyright: ® 2025 THE AUTHORS.
α-Synuclein interacts directly with AP2 and regulates its binding to synaptic membranes

1 month ago | jbc.org | Karina Vargas |Woods Hole |Ian Mooney |David Owen

Keywordsα-synucleinAP2synaptic vesicle recyclingendocytosissynapseIntroductionα-Synuclein is a small presynaptic protein that regulates synaptic vesicle trafficking under physiological conditions and that aberrantly aggregates throughout neurons in Parkinson’s disease, dementia with Lewy bodies, and other related synucleinopathies (1-4).
Unstructured protein domains stabilize RNA binding and mediate RNA folding by AUF1

1 month ago | jbc.org | Nina Lee |Patrick J. McGinnis |Haley H. Tilley |Grace A. Acle

Keywords AU-rich element AU‐rich element RNA‐binding protein 1 (AUF1) RNA binding protein RNA folding fluorescence anisotropy fluorescence resonance energy transfer (FRET) thermodynamics Abbreviations and nomenclature ARE (AU-rich element) AUBP (ARE-binding protein) AUF1 (ARE/poly(U)-binding/degradation factor 1) B (biotin) CD (circular dichroism) Cy3 (cyanine-3) EK (enterokinase) EMSA (electrophoretic mobility shift assay) Fl (fluorescein) GnHCl (guanidine hydrochloride) RNP...
The levels of the long non-coding RNA MALAT1 affect cell viability and modulate TDP-43 binding to mRNA in the nucleus

Jan 19, 2025 | jbc.org | Simone Hall |Jonathan Zhu |Lauren Ellis

KeywordsLong non-coding RNAmRNARNA binding proteinRNA-protein interactionmRNA stabilitygene expressionMALAT1TAR DNA-binding protein 43 (TDP-43) (TARDBP)neurodegenerationIntroductionRNA-protein interactions regulate gene expression, splicing, and cell growth. Genome-wide studies of RNA-protein interactions suggest that eukaryotic cells contain complex networks of binding interactions between RNAs and proteins, including mRNAs, non-coding RNAs, splicing factors and other RNA binding proteins.
Biomedical Effects of Protein Arginine Methyltransferase Inhibitors

Jan 16, 2025 | jbc.org | Mengtong Cao |Terry Nguyen |Jiabao Song |Y. Zheng

KeywordsPTMPRMTprotein arginine methylationepigeneticsMTAMTAPinhibitordrug discoverypharmacologyIntroductionCovalent post-translational modifications (PTMs) of proteins are involved in the regulation of multifaceted biological processes in cells such as transcription, translation, protein-protein interaction, signal transduction, and RNA metabolism (1,2).
Rad5 and Ubc4 directly ubiquitinate PCNA at Lys164 in vitro

Jan 15, 2025 | jbc.org | Kai Zhang

Research ArticleArticles in Press108192Open accessDepartment of Biochemistry and Molecular Biology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The province and ministry co-sponsored collaborative innovation center for medical epigenetics, Tianjin Key Laboratory of Medical Epigenetics, Tianjin Medical University, 300070 Tianjin, P. R.
USP1 promotes pancreatic cancer progression and autophagy by deubiquitinating ATG14

Jan 13, 2025 | jbc.org | Cheeloo College |Guangxi Normal

Research ArticlesArticles in Press108190Open access aInstitute of Immunopharmaceutical Sciences, NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, Key Laboratory of Chemical Biology, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China bState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin, Guangxi, China Publication History: Received October 28,...
Recent advances in the synthesis and application of biomolecular condensates

Jan 13, 2025 | jbc.org | Shenzhen Institutes |Hong Kong Baptist |Kowloon Tong

Keywordsbiomolecular condensatesphase separationsynthetic biologySBMCsde novo synthesisIntroductionCells execute programmed processes by organizing the intracellular space into small substructures, known as organelles or compartments (1). While eukaryotic cells are characterized by membrane-bound organelles, both prokaryotic and eukaryotic cells encompass a group of membraneless organelles named biomolecular condensates (BMCs).
Tau destabilization in a familial deletion mutant K280 accelerates its fibrillization and enhances the seeding effect

Jan 13, 2025 | jbc.org | Gary Chen |Academia Sinica

Key WordsTaustabilityfibrillizationseedingtauopathyIntroductionTauopathies cover a range of neurodegenerative diseases characterized by the presence of neuronal tau inclusions, including Alzheimer’s disease (AD), Pick’s disease, progressive supranuclear palsy, corticobasal degeneration, and frontotemporal dementia and Parkinsonism linked to chromosome 17 (1). Under physiological conditions, tau functions as a microtubule-binding protein that stabilizes microtubules.