The Journal of Biological Chemistry

The Journal of Biological Chemistry is a scientific journal that publishes peer-reviewed research on a weekly basis. It was founded in 1905 and has been published by the American Society for Biochemistry and Molecular Biology since 1925. This journal focuses on studies related to biochemistry and molecular biology. The current editors-in-chief are Martha Fedor and Herbert Tabor. Articles become freely accessible to the public one year after their publication, and those that are accepted for publication can be accessed for free right away on the journal's website.

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Articles

The human autophagy-initiating complexes ULK1C and PI3KC3-C1

1 week ago | jbc.org | James Hurley

IntroductionMacroautophagy, hereafter referred to as autophagy, is a fundamental process in eukaryotic cells that maintains homeostasis by degrading unnecessary or damaged cellular components. Dysfunction of autophagy is implicated in numerous human diseases, including cancer, inflammatory diseases, neurodegenerative disorders, and infections caused by viruses and bacteria (1, 2).
Bacterial genome encoded ParMs

2 weeks ago | jbc.org | Samson Ali |Adrian Koh |David Popp |Kotaro Tanaka

KeywordsDNA segregationnucleotide hydrolysisplasmidParMParCMR systemIntroductionIn contrast to the random diffusion mode of segregation for high copy number plasmids, low copy number plasmids require an active plasmid maintenance system to ensure equal distribution to daughter cells during cell division (1, 2). Polymerizing ParM proteins belong to the ParCMR system, one of the three known types of the segregation or partition (par) systems that aid plasmid inheritance.
The molecular basis of T cell receptor recognition of citrullinated tenascin-C presented by HLA-DR4

3 weeks ago | jbc.org | Tiing Jen Loh |Ravi Sharma |Lars Klareskog

IntroductionRheumatoid arthritis (RA) is a T cell-mediated autoimmune disease which affects primarily the joints, and its progression leads to significant morbidity and reduced life expectancy. The disease has a prevalence of 0.5% worldwide and over 500,000 people in Australia (1,2). A hallmark characteristic of RA is the presence of anti-citrullinated protein antibodies (ACPA) in sera, for which >70% of the RA patients being ACPA seropositive in established RA and prior to disease onset (3-9).
Map of the Neuronal O-glycoproteome Reveal Driver Functions in the Regulated Secretory Pathway

1 month ago | jbc.org | Thomas D. Madsen |John Hintze |Emily J. Shiplett |Leo A. Dworkin

Introduction:Glycosylation is the most abundant and diverse type of posttranslational modification (PTM) of proteins, and glycans serve a plethora of roles in fine-tuning protein functions and serving as ligands in important interactions (1, 2).
Structure-function analysis defines the minimal functional C-terminal domain of the variant surface glycoprotein of Trypanosoma brucei

1 month ago | jbc.org | Nicola Jones |Markus Engstler

Keywordscell surfacevariant surface glycoproteinstructure-functionmutagenesisprotein domainGlycosylphosphatidylinositol (GPI) anchorTrypanosoma bruceiTrypanosoma congolenseIntroductionThe bloodstream form of Trypanosoma brucei is covered by a homogenous, dense glycoprotein layer, which, at a given time, consists almost entirely of a single isoform of the large family of GPI-anchored variant surface glycoproteins (VSGs) (1-3).
Live Cell Analysis of Mobility and Decay Kinetics of the Histone Variant H3.3

1 month ago | jbc.org | Vishal Nehru |David Ball |Abhishek Mukherjee |Daisuke Kurotaki

Research ArticleArticles in Press108557Open access 1Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA 2Section on Neural Developmental Dynamics, Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA 3CCR/LRBGE Optical Microscopy Core, National Cancer...
Nuclear Protein FNBP4: A Novel Inhibitor of Non-diaphanous Formin FMN1-Mediated Actin Cytoskeleton Dynamics

1 month ago | jbc.org | Shubham Das |Saikat Das |Amrita Maity |Sankar Maiti

Research ArticleArticles in Press108550Open accessDepartment of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, West Bengal, IndiaPublication History:Received January 9, 2025; Revised April 7, 2025; Accepted April 11, 2025; Published online April 30, 2025DOI: 10.1016/j.jbc.2025.108550 External LinkAlso available on ScienceDirect External LinkCopyright: ® 2025 THE AUTHORS.
α-Synuclein interacts directly with AP2 and regulates its binding to synaptic membranes

2 months ago | jbc.org | Karina Vargas |Woods Hole |Ian Mooney |David Owen

Keywordsα-synucleinAP2synaptic vesicle recyclingendocytosissynapseIntroductionα-Synuclein is a small presynaptic protein that regulates synaptic vesicle trafficking under physiological conditions and that aberrantly aggregates throughout neurons in Parkinson’s disease, dementia with Lewy bodies, and other related synucleinopathies (1-4).
Unstructured protein domains stabilize RNA binding and mediate RNA folding by AUF1

Mar 25, 2025 | jbc.org | Nina Lee |Patrick J. McGinnis |Haley H. Tilley |Grace A. Acle

Keywords AU-rich element AU‐rich element RNA‐binding protein 1 (AUF1) RNA binding protein RNA folding fluorescence anisotropy fluorescence resonance energy transfer (FRET) thermodynamics Abbreviations and nomenclature ARE (AU-rich element) AUBP (ARE-binding protein) AUF1 (ARE/poly(U)-binding/degradation factor 1) B (biotin) CD (circular dichroism) Cy3 (cyanine-3) EK (enterokinase) EMSA (electrophoretic mobility shift assay) Fl (fluorescein) GnHCl (guanidine hydrochloride) RNP...
The levels of the long non-coding RNA MALAT1 affect cell viability and modulate TDP-43 binding to mRNA in the nucleus

Jan 19, 2025 | jbc.org | Simone Hall |Jonathan Zhu |Lauren Ellis

KeywordsLong non-coding RNAmRNARNA binding proteinRNA-protein interactionmRNA stabilitygene expressionMALAT1TAR DNA-binding protein 43 (TDP-43) (TARDBP)neurodegenerationIntroductionRNA-protein interactions regulate gene expression, splicing, and cell growth. Genome-wide studies of RNA-protein interactions suggest that eukaryotic cells contain complex networks of binding interactions between RNAs and proteins, including mRNAs, non-coding RNAs, splicing factors and other RNA binding proteins.