Evidence-Based Dentistry

20 hours ago | nature.com | Shreya Rao |David Vidal |Keo Shaw |Danny Tobey |Shira Zilberstein |Manesh R. Patel | +7 more

As artificial intelligence (AI) becomes further embedded in healthcare, healthcare delivery organizations (HDOs) must navigate a complex regulatory landscape. Health AI Partnership (HAIP) has created 31 best practice guides to inform the development, validation, and implementation of AI products. Here, we map the most common principles found in 8 key AI regulatory frameworks to HAIP recommended best practices to provide practical insights for compliance with expanding AI regulations.

1 day ago | nature.com | Shengsong Xu |Xiao Wang |Jinyi Xu |Xingyu Lei |MengYi Wang |Xiao Yang | +3 more

To investigate the causal relationship between depression, anxiety, and myopia. The multivariable Mendelian randomization (MR) design using summary statistics from independent genome-wide association studies (GWAS) was employed. The anxiety and depression, were used as exposures, and myopia was used as the outcome. Genetic variants associated with depression were derived using GWAS summary statistics from the FinnGen consortium database. Genetic variants associated with anxiety were derived from the Psychiatric Genomics consortium. The inverse-variance-weighted method was the main applied analytic tool and was complemented with comprehensive sensitivity analyses. A total of 21, 10 SNPs were selected as instrumental variables for depression and anxiety, respectively. Based on the IVW analysis, both depression (OR = 1.010, 95% CI = 1.002–1.018, P = 0.016) and anxiety (OR = 1.083, 95%CI = 1.022–1.149, P = 0.008) increased the risk of myopia. After adjusting in the multivariable MR, the IVW and Egger methods indicated that depression (OR = 1.004, 95%CI = 1.000–1.008, P = 0.030) or anxiety (OR = 1.004, 95%CI = 1.001–1.008, P = 0.026) was still associated with elevated risks of myopia. The current study identified a causal relationship between anxiety, depression, and an increased risk of myopia. These observations suggest that when developing strategies to control myopia, it is also important to focus on the mental health of children. Further detailed research is needed to fully understand this issue.

1 day ago | nature.com | Jack Leeming

This article is also available as apdf version. The winners of Nature’s 2025 #ScientistAtWork photo competition are drawn entirely from fieldwork entries, taking viewers on a voyage of scientific discovery that includes the Arctic and Antarctic circles, both sides of the Pacific Ocean, and a shot from atop a Greek mountain. Nature’s careers team received more than 200 entries from researchers around the world.

2 days ago | nature.com | Yi Ju |Stephen Kent

Developing nanomedicines that avoid fast blood clearance while retaining targeting specificity in vivo is inherently challenging. Leveraging the individual biomolecular corona, optimizing the nature of targeting ligands and exploring alternative stealth formulations might be the key to engineering tailored nanomedicine approaches.

2 days ago | nature.com | Elizabeth Gibney

OpenAI is best known for ChatGPT — the free-to-use, large language model-based chatbot that became a household name after its debut in 2022. The firm, in San Francisco, California, has since released a string of cutting-edge artificial intelligence (AI) tools, including ‘reasoning’ models that use step-by-step ‘thought’ processes to specialize in logical tasks. OpenAI’s ‘deep research’ tool: is it useful for scientists?