Evidence-Based Dentistry

Evidence-based dentistry (EBD) focuses on using the most up-to-date scientific research to make informed decisions in dental care. This method emphasizes the importance of integrating relevant scientific information with the dentist's own professional knowledge and skills. By adopting EBD, dental professionals can keep pace with the latest advancements in treatment options, ensuring that patients receive the best possible care. In the 1990s, a new educational framework was created to merge current research with clinical practice, enabling healthcare providers to improve patient outcomes. This initiative was spearheaded by Gordon Guyatt and the Evidence-Based Medicine Working Group at McMaster University in Ontario, Canada.

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Is AI watching you? The hidden links between research and surveillance

2 days ago | nature.com | Benjamin Thompson |Shamini Bundell

Download the Nature Podcast 25 June 2025We’d like to learn more about our listeners, please help us out by filling in this short survey. In this episode:00:45 Is AI-research being co-opted to keep track of people? A significant amount of research in the AI field of computer vision is being used to analyse humans in ways that support the development of surveillance technologies, according to new research.
Molecular mechanism of pH sensing and activation in GPR4 reveals proton-mediated GPCR signaling - Cell Discovery

3 days ago | nature.com | Chongzhao You |Shimeng Guo |Tianwei Zhang |Xinheng He |Youwei Xu |Yi Jiang | +1 more

AbstractMaintaining pH homeostasis is critical for cellular function across all living organisms. Proton-sensing G protein-coupled receptors (GPCRs), particularly GPR4, play a pivotal role in cellular responses to pH changes. Yet, the molecular mechanisms underlying their proton sensing and activation remain incompletely understood. Here we present high-resolution cryo-electron microscopy structures of GPR4 in complex with G proteins under physiological and acidic pH conditions.
Comparison of induction with arsenic trioxide or chemotherapy in a real-world cohort of patients with high-risk acute promyelocytic leukemia - Leukemia

3 days ago | nature.com | Delphine Lebon |Nicolas Duployez |Christophe Willekens |Thomas Cluzeau |Christian Récher |Mathilde Hunault-Berger | +1 more

AbstractFront-line treatment with all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) is superior to standard ATRA and chemotherapy (CHT) in patients with low-/intermediate-risk acute promyelocytic leukemia (APL). However, for high-risk (HR) patients (defined as those with a white blood cell count ≥ 10×10⁹/L), the role of ATRA-ATO is subject to debate, and study data are scarce.
TSC22 domain family member 3 links natural killer cells to CD8+ T cell-mediated drug hypersensitivity - Signal Transduction and Targeted Therapy

1 week ago | nature.com | Zhenzhen Wang |Joshua Gardner |Xiaoli Meng

AbstractSevere cutaneous adverse drug reactions (SCARs) are life-threatening diseases, which are associated with human leukocyte antigen (HLA) risk variants. However, the low positive predictive values of HLA variants suggest additional factors influence disease susceptibility. Using dapsone hypersensitivity syndrome (DHS) as a paradigm for SCARs, we show that the DHS patients harbor a sex-related global reduction in blood NK cells, contributing to the higher incidence of reactions in females.
A survey of pathogenic involvement in non-communicable human diseases - Communications Medicine

1 week ago | nature.com | Michael Lape |Daniel J. Schnell |Shannon O’Connor |Nathan Salomonis |Lisa Martin |Leah C. Kottyan

AbstractMany relationships between pathogens and human disease are well-established. However, only a small fraction involve diseases considered non-communicable (NCDs). In this study, we sought to leverage the vast amount of newly available electronic health record data to identify potentially novel pathogen-NCD associations and find additional evidence supporting known associations.
Early grant success attracts more funding: study of 100,000 applicants hints at why

1 week ago | nature.com | Holly Else

Perseverance is key when it comes to securing science funding, found an analysis of more than 100,000 grant applicants that looked at how early success affects future prospects. The research shows how the Matthew effect — a phenomenon describing how those with an early advantage or success tend to accumulate more over time — could be driving inequity in academia. Previous work has suggested that those who win funding early in their career are more successful later down the line.
Developing astronomers in Africa: ‘We wanted to create a discipline’

1 week ago | nature.com | Sarah Wild

In 2005, when South Africa and its partner countries in Africa submitted a proposal to host the world’s largest radio telescope, called the Square Kilometre Array, the continent had five radioastronomers, all based in South Africa. That year, the country embarked on a targeted human-capital development programme to develop talent needed to build, operate and use radio telescopes, which collect radio signals emitted by celestial objects.
Bringing men into conversations about parenting in academia

1 week ago | nature.com | Amanda Heidt

Carers working in academia — the vast majority of whom are women — face disproportionate career burdens, and the cultural shift needed to correct that imbalance will require considerable action from men. To advance that cause, the international non-profit organization Mothers in Science (MIS) is launching a global awareness campaign to amplify the voices of fathers who are redefining fatherhood and advancing gender equity.
Africa’s chief diplomat for vaccine manufacturing

1 week ago | nature.com | Abdullahi Tsanni

This article is part of an occasional series in which Nature profiles scientists with unusual career histories or outside interests. More than 300 people gathered at Senegal’s seaside Hôtel Terrou-bi for the centenary celebration of the Pasteur Institute of Dakar (IPD) last December, an event at which the Pasteur Network — which has 32 institutes in 25 countries — toasted the IPD’s achievements.
Intercellular flow dominates the poroelasticity of multicellular tissues - Nature Physics

1 week ago | nature.com | Fan Liu |Hui Li

AbstractThe mechanical characteristics of cells and extracellular matrices—such as elasticity, surface tension and viscosity—can influence diseases such as fibrosis and tumour metastasis. Multicellular tissues have traditionally been modelled as viscoelastic materials, which overlooked the abundance of intercellular space and intercellular flow within the structure.