Trends in Neurosciences

For more than 40 years, Trends in Neurosciences (TINS) has been a key resource for insightful reviews and discussions in various areas of neuroscience. Published monthly and peer-reviewed, the journal features articles selected by the Editor and written by top researchers in their fields. TINS showcases groundbreaking developments in brain research, represents the global neuroscience community, and emphasizes the impact of neuroscientific studies on medicine and society.

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Testing the carbohydrate-insulin model: Short-term metabolic responses to consumption of meals with varying glycemic index in healthy adults

2 days ago | cell.com | Ying Liu |Huihui Mei |Li Xue |Chuanli Cheng |Yingtong Wu |Chao Zou | +11 more

During preparation of Figure 2F, an error occurred in Excel that distorted the values of percentage energy from fat. This error has now been corrected online. We, the authors, apologize for any confusion this may have caused and thank Jenni Brand-Miller and Mark Haub, who spotted the problem and drew it to our attention.
Molecular arms in microbial defense: Argonautes and Cas4 nucleases team up

2 weeks ago | cell.com | Sucharita Sarkar |Ian MacRae |Ian Macrae

Get full text accessLog in, subscribe or purchase for full access. References1. Bobadilla Ugarte, P. ∙ Halter, S. ∙ Mutte, S.K. ... Cyanobacterial Argonautes and Cas4 family nucleases cooperate to interfere with invading DNAMol. Cell. 2025; 85:1920-1937.e102. Bernstein, E. ∙ Caudy, A.A. ∙ Hammond, S.M. ... Role for a bidentate ribonuclease in the initiation step of RNA interferenceNature. 2001; 409:363-3663. Zamore, P.D. ∙ Tuschl, T. ∙ Sharp, P.A. ...
Sickle cell disease induces chromatin introversion and ferroptosis in CD8+ T cells to suppress anti-tumor immunity

3 weeks ago | cell.com | Zilong Zhao |Benxia Hu |Yalan Deng |Melinda Soeung |Jun Yao |Lanxin Bei | +25 more

Keywords sickle cell disease renal medullary carcinoma ferroptosis genomic architecture alteration Hi-C H2S SLC7A11 SMARCB1 immune checkpoint inhibitors CD8+ T cells Introduction Sickle cell disease (SCD), the most prevalent inherited blood disorder,1 arises from the homozygous HbS mutation (GAG>GTG: βGlu6Val), causing hemoglobin abnormalities that make red blood cells (RBCs) assume a sickle or crescent shape.2 Individuals with SCD have RBCs prone to hemolysis, leading to vaso-occlusive...
Sickle cell disease induces chromatin introversion and ferroptosis in CD8+ T cells to suppress anti-tumor immunity

3 weeks ago | cell.com | Zilong Zhao |Benxia Hu |Yalan Deng |Melinda Soeung |Jun Yao |Lanxin Bei | +25 more

Keywords sickle cell disease renal medullary carcinoma ferroptosis genomic architecture alteration Hi-C H2S SLC7A11 SMARCB1 immune checkpoint inhibitors CD8+ T cells Introduction Sickle cell disease (SCD), the most prevalent inherited blood disorder,1 arises from the homozygous HbS mutation (GAG>GTG: βGlu6Val), causing hemoglobin abnormalities that make red blood cells (RBCs) assume a sickle or crescent shape.2 Individuals with SCD have RBCs prone to hemolysis, leading to vaso-occlusive...
Matter Forums: Face-to-face still matters

4 weeks ago | cell.com | Steve Cranford

Main textThe recent global pandemic required an abrupt shift in how science was shared globally, for better or for worse. Virtual meetings were the new normal and have persisted (in a more limited context) past the pandemic's prime. There are numerous pros and cons to moving science online, but is it reflective of a larger trend, merely accelerated by pandemic restrictions?
All-optical synaptic devices utilizing 2D polymer film for logic operations and integrated edge computing

4 weeks ago | cell.com | Jinyong Li |Yue Hu |Yang Gao |Bin Zhang |Fuzhen Xuan |Jinglong Bi | +1 more

Keywords 2D polymer all-optical synaptic devices logic operations edge computing Introduction Neuromorphic computing is a novel architecture that promises to overcome the von Neumann bottleneck by emulating the brain’s ability to perceive, process, and store information efficiently.1,2 Inspired by the brain’s highly parallel and low-energy self-learning capabilities, neuromorphic systems aim to revolutionize computing by addressing the bottlenecks caused by the physical separation of memory...
The recency and geographical origins of the bat viruses ancestral to SARS-CoV and SARS-CoV-2

4 weeks ago | cell.com | Jonathan Pekar |Spyros Lytras |Mahan Ghafari |Andrew Magee |Edyth Parker |Yu Wang | +13 more

Keywords molecular epidemiology sarbecoviruses virus evolution phylogeography Introduction Horseshoe bats (Rhinolophus spp.) are the main hosts of the Sarbecovirus subgenus1 (genus Betacoronavirus, family Coronaviridae) and, likely via virus transmission through transient intermediate species, were the source of SARS-CoV (referred to hereafter as SARS-CoV-1, now extinct) and SARS-CoV-2.2,3,4 Since the first emergence of SARS-CoV-1 in Guangzhou, Guangdong Province, in 2002 and SARS-CoV-2...
Synergistic role of gut-microbial L-ornithine in enhancing ustekinumab efficacy for Crohn’s disease

4 weeks ago | cell.com | Zhenyu Wang |Li Tian |Yi Jiang |Lijun Ning |Xiaoqiang Zhu |Xuejie Chen | +13 more

KeywordsCrohn’ s diseaseustekinumabL-ornithineFaecalibacterium prausnitziiIL-12RB1EGR1IL-12/IL-23 signaling pathwayTh17 cellmulti-omicsmediation analysisGet full text accessLog in, subscribe or purchase for full access. References1. Danese, S. ∙ Vuitton, L. ∙ Peyrin-Biroulet, L. Biologic agents for IBD: practical insightsNat. Rev. Gastroenterol. Hepatol. 2015; 12:537-5452. Cao, Q. ∙ Chen, C. ∙ Gao, X. ...
ZNF574 is a quality control factor for defective ribosome biogenesis intermediates

1 month ago | cell.com | Jared Akers |Michael LaScola |Adrian Bothe |Hanna Suh |Carmen Jung |Zachary D. Stolp | +13 more

Keywordsribosome assemblyquality controlubiquitin-proteasome systemCRISPRidevelopmentribosomopathyIntroductionThe eukaryotic ribosome is a complex molecular machine responsible for translating mRNA to protein.
Tracing the evolutionary history of the CCR5delta32 deletion via ancient and modern genomes

1 month ago | cell.com | Kirstine Ravn |Jonas Meisner |Lasse Danielsen |Michael Eriksen Benros |Thorfinn Sand Korneliussen |Martin Sikora | +6 more

Keywords CCR5 CCR5delta32 HIV-1 infection resistance pleiotropy haplotype recombination ancient genomes evolution positive selection immune genes Introduction Humans have been exposed to pathogens over the course of our evolutionary history, and adaptations to them have left numerous signatures in our genomes.1,2,3 In recent years, evidence for selection has been found in genes involved in the development of tolerance against intracellular pathogens and in the inflammatory response against...