Trends in Neurosciences

For more than 40 years, Trends in Neurosciences (TINS) has been a key resource for insightful reviews and discussions in various areas of neuroscience. Published monthly and peer-reviewed, the journal features articles selected by the Editor and written by top researchers in their fields. TINS showcases groundbreaking developments in brain research, represents the global neuroscience community, and emphasizes the impact of neuroscientific studies on medicine and society.

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Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation

1 week ago | cell.com | Diana Vara-Ciruelos |Madhumita Dandapani |Fiona Russell |Katarzyna M. Grzes |Abdelmadjid Atrih |Marc Foretz | +4 more

Main text(Cell Reports , 690–698.e1–e4; April 16, 2019)A reader pointed out a problem with Figure 4E in this paper. The anti-phospho-4EBP1 western blots for F04 and F15 cells were flagged as potential duplicates. When the original data was requested by the editor, the authors realized that one of the image files was accidentally mislabelled.
Spatially restricted and ontogenically distinct hepatic macrophages are required for tissue repair

3 weeks ago | cell.com | Anna Bujko |Zhuangzhuang Liu |Paul Collins |Sara Schuermans |Christian Maueröder |Seraja Amstelveen | +24 more

Main text(Immunity 58, 362–380.e1–e10; February 11, 2025)Following publication, the authors identified an error in Figure S7. Specifically, during preparation of the accepted manuscript for publication, an incorrect version of the figure was included that contained two additional figure panels. This led to a mismatch in calling out the correct figure panels in the Results section, where the figures presented as S7H and S7I were referred to as S7F and S7G.
Early prediction of the failure probability distribution for energy-storage driven by domain-knowledge-informed machine learning

3 weeks ago | cell.com | Maher B. Alghalayini |Stephen Harris |Marcus M. Noack

Keywordsmachine learningenergy storageearly lifetime predictionfailure probability distributionGaussian processesexperimental stopping criteriondistribution entropydomain-informed machine learningIntroductionAs the need for energy increases at an accelerating rate, there has been a global adoption of additional energy sources, such as solar and wind.
I’m busy: The search for peer reviewers

3 weeks ago | cell.com | Steve Cranford

Main textPeer review is a little bit of a contentious topic lately, with the proliferation of journal titles being launched and submissions draining the community of time and effort … with little reward or recognition. What used to be somewhat of a gentleman’s agreement between author and journal has turned into the academic equivalent of arranging deck chairs on the Titanic.
Coordinated social interaction states revealed by probabilistic modeling of zebrafish behavior

3 weeks ago | cell.com | Sarah Josephine Stednitz |Andrew Lesak |Adeline Fecker |Peregrine Painter |Phil Washbourne |Luca Mazzucato | +1 more

keywordssocial behaviorzebrafishdyadmultisensoryvisionmechanosensationhidden markov modelprobabilistic modelGet full text accessLog in, subscribe or purchase for full access. References1. Suriyampola, P.S. ∙ Shelton, D.S. ∙ Shukla, R. ... Zebrafish social behavior in the wildZebrafish. 2016; 13:1-82. Engeszer, R.E. ∙ Patterson, L.B. ∙ Rao, A.A. ... Zebrafish in the wild: a review of natural history and new notes from the fieldZebrafish. 2007; 4:21-403. Dreosti, E. ∙ Lopes, G. ∙ Kampff, A.R. ...
Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV

3 weeks ago | cell.com | Jessica Davidson |Raghav Jain |Thomas Kizzar |Gisela Geoghegan |Daniel Nesbitt |Amy Cavanagh | +20 more

Keywordslysosomelipidomicslivercold exposureliquid chromatography-mass spectrometryLC-MStranscription factor EBTFEBphospholipase A2 G15Pla2g15bis(monoacylglycero)phosphateBMPIntroductionThe liver maintains energy homeostasis in mammals by acting as a metabolic transistor switching between providing glucose or lipids for peripheral tissue catabolism. In the fed state, the liver is a sink for excess glucose to maintain normoglycemia.
Testing the carbohydrate-insulin model: Short-term metabolic responses to consumption of meals with varying glycemic index in healthy adults

3 weeks ago | cell.com | Ying Liu |Huihui Mei |Li Xue |Chuanli Cheng |Yingtong Wu |Chao Zou | +11 more

During preparation of Figure 2F, an error occurred in Excel that distorted the values of percentage energy from fat. This error has now been corrected online. We, the authors, apologize for any confusion this may have caused and thank Jenni Brand-Miller and Mark Haub, who spotted the problem and drew it to our attention.
Testing the carbohydrate-insulin model: The data are supportive!

3 weeks ago | cell.com | David Ludwig |Jennie C Brand-Miller |Cara B. Ebbeling |Mark Friedman |Nicholas Norwitz |Adrian Soto-Mota

LetterVolume 37, Issue 6p1239-1240 1New Balance Foundation Obesity Prevention Center, Boston Children’s Hospital, Boston, MA, USA 2Harvard Medical School, Boston, MA, USA 3Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA 4Steno Diabetes Center Copenhagen, Herlev, Denmark 5School of Life and Environmental Sciences and Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia 6Monell Chemical Senses Center, Philadelphia, PA, USA 7Metabolic...
Calcium-responsive phosphorylation of SlLHP1b epigenetically suppresses auxin synthesis to control drought-induced flower drop in tomato

3 weeks ago | cell.com | Siqi Ge |Sai Wang |XianFeng Liu |Lina Cheng |Ruizhen Li |Yang Liu | +8 more

Keywordsdroughttomatoflower dropcalcium signalingphosphorylationH3K27me3auxin synthesisGet full text accessLog in, subscribe or purchase for full access. References1. Tucker, M.L. ∙ Kim, J. Abscission research: what we know and what we still need to studyStewart Postharvest Rev. 2015; 11:1-72. Taylor, J.E. ∙ Whitelaw, C.A.Signals in abscissionNew Phytol. 2001; 151:323-3403. Shi, Y. ∙ Song, B. ∙ Liang, Q. ... Molecular regulatory events of flower and fruit abscission in horticultural plantsHortic. Plant J.
Bacteroides sphingolipids promote anti-inflammatory responses through the mevalonate pathway

4 weeks ago | cell.com | Eric Brown |Emily Temple |Sarah Jeanfavre |Julian Avila-Pacheco |Noel Taylor |Kai Liu | +8 more

KeywordssphingolipidsBacteroidesouter membrane vesiclesOMVsmevalonate pathwayIL-10dendritic cellsimmunometabolismanti-inflammatory signalingCerPEmicrobiomeGet full text accessLog in, subscribe or purchase for full access. References1. Integrative HMP (iHMP) Research Network ConsortiumThe Integrative Human Microbiome ProjectNature. 2019; 569:641-6482. Yatsunenko, T. ∙ Rey, F.E. ∙ Manary, M.J. ... Human gut microbiome viewed across age and geographyNature. 2012; 486:222-2273.