Trends in Neurosciences

For more than 40 years, Trends in Neurosciences (TINS) has been a key resource for insightful reviews and discussions in various areas of neuroscience. Published monthly and peer-reviewed, the journal features articles selected by the Editor and written by top researchers in their fields. TINS showcases groundbreaking developments in brain research, represents the global neuroscience community, and emphasizes the impact of neuroscientific studies on medicine and society.

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Now you see me, now you don’t: What and how viral RNAs are detected by cytoplasmic pattern-recognition receptors

6 days ago | cell.com | Raul Andino |Daniel Darling

Get full text accessLog in, subscribe or purchase for full access. References1. Genoyer, E. ∙ Wilson, J. ∙ Ames, J.M. ... Exposure of negative-sense viral RNA in the cytoplasm initiates innate immunity to West Nile virusMol. Cell. 2025; 85:1147-1161.e92. Chow, K.T. ∙ Gale, Jr., M. ∙ Loo, Y.-M. RIG-I and Other RNA Sensors in Antiviral ImmunityAnnu. Rev. Immunol. 2018; 36:667-6943. Yoneyama, M. ∙ Kikuchi, M. ∙ Natsukawa, T. ...
PP1/PNUTS phosphatase binds the restrictor complex and stimulates RNA Pol II transcription termination

1 week ago | cell.com | Benjamin Erickson |Roman O Fedoryshchak |Nova Fong |Ryan Sheridan |Keira larson |Anthony J. Saviola | +4 more

KeywordsPol II CTD Ser5 phosphorylationCTD dephosphorylationPP1 phosphataserestrictorWDR82ZC3H4transcription terminationtranscription elongationResearch topic(s)CP: Molecular biologyIntroductionA large fraction of promoters in multicellular organisms have bidirectional character and give rise to both sense and divergent antisense transcription, which must eventually terminate to prevent interference with neighboring genes and collisions with replication forks.
Bridging the gap: The future of cancer research and clinical oncology in Cancer Cell

1 week ago | cell.com | Steve Mao

Main textOver the past five years, Cancer Cell has undergone a transformative evolution, reflecting the increasing multidisciplinary and integrative nature of cancer research. As editor-in-chief, it has been both a privilege and a profound responsibility to guide this journal through a period of significant change and growth, ensuring that it remains at the forefront of cancer research while adapting to the evolving needs of the scientific community.
Traffic Jam activates the Flamenco piRNA cluster locus and the Piwi pathway to ensure transposon silencing and Drosophila fertility

2 weeks ago | cell.com | Austin Rivera |Jou-Hsuan Lee |Shruti Gupta |Linda Yang |Raghuveera Kumar Goel |Joseph Zaia | +1 more

Keywordstranscription factorspiRNA pathway regulationtransposon silencingDrosophila ovary follicle cell developmentResearch topic(s)CP: Molecular biologyIntroductionIn the Drosophila ovary, the germline compartment of nurse cells and the oocyte are encompassed by the somatic compartment of follicle cells.
Hijacking the powerhouse: Mitochondrial transfer and mitophagy as emerging mechanisms of immune evasion

2 weeks ago | cell.com | Maria T. Diaz-Meco |Juan Linares |Jorge Moscat

Get full text accessLog in, subscribe or purchase for full access. References1. Ikeda, H. ∙ Kawase, K. ∙ Nishi, T. ... Immune evasion through mitochondrial transfer in the tumour microenvironmentNature. 2025; 638:225-2362. Arner, E.N. ∙ Rathmell, J.C.Metabolic programming and immune suppression in the tumor microenvironmentCancer Cell. 2023; 41:421-4333. Thommen, D.S. ∙ Schumacher, T.N.T Cell Dysfunction in CancerCancer Cell. 2018; 33:547-5624. Hanahan, D.
Male secreted short glycoproteins link sperm competition to the reproductive isolation of species

3 weeks ago | cell.com | Justin Van Goor |Asan Turdiev |Savannah J. Speir |Jillian Manning |Eric S. Haag

Main text(Current Biology 35, 911–917.e1–e5; February 24, 2025)In the STAR Methods section of this paper, errors were made in describing two C. briggsae genotypes. First, strain CP217 is described in the key resources table as harboring the allele Cbr-msrp-3(nm86). nm86 is actually an allele of Cbr-msrp-1, as was correctly stated in the paper’s main text.
Can we talk? The cryptic communications of hepatic stellate cells in lipid metabolism

3 weeks ago | cell.com | Scott Friedman

Get full text accessLog in, subscribe or purchase for full access. References1. Hansen, D. ∙ Jensen, J.E.R. ∙ Andersen, C.A.T. ... Hepatic stellate cells regulate liver fatty acid utilization via plasmalemma vesicle-associated proteinCell Metab. 2025; 37:971-986.e82. Kovtun, O. ∙ Tillu, V.A. ∙ Ariotti, N. ... Cavin family proteins and the assembly of caveolaeJ. Cell Sci. 2015; 128:1269-12783. Zhang, Y. ∙ Jia, X. ∙ Wang, Y. ...
Lactate controls cancer stemness and plasticity through epigenetic regulation

3 weeks ago | cell.com | Nguyen NGUYEN |NGuyen nguyen |Sira Gevers |Rutger Kok |Lotte M. Burgering |Hannah K. Neikes | +11 more

Keywords cancer metabolism stem cells cell types cell plasticity differentiation organoids live imaging single-cell tracking heterogeneity cell-cell interactions Introduction Epithelial tissue maintenance relies on self-renewing stem cells, with mutations in stemness-regulating pathways causing uncontrolled cell proliferation and tumor formation.1 In the intestine, WNT activity is the main regulator of the stem cell state, and its overactivation drives tumorigenesis.2,3,4 Despite a general...
Decoding human chemical reprogramming: mechanisms and principles

3 weeks ago | cell.com | Lin Cheng |Yanglu Wang |Jingyang Guan |Hongkui Deng

Keywordschemical reprogrammingsmall moleculeshuman chemically induced pluripotent stem cells (hCiPSCs)plasticitypluripotencyregenerationGet full text accessLog in, subscribe or purchase for full access. References1. Gurdon, J.B.The developmental capacity of nuclei taken from intestinal epithelium cells of feeding tadpolesJ. Embryol. Exp. Morpholog. 1962; 10:622-6402. Takahashi, K. ∙ Yamanaka, S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factorsCell.
Concerns about ancient DNA sequences reported from a Late Pleistocene individual from Southeast Asia

1 month ago | cell.com | Daniel R. Tabin |Nick Patterson |Matthew Mah |David Reich

Get full text accessLog in, subscribe or purchase for full access. References1. Zhang, X. ∙ Ji, X. ∙ Li, C. ... A Late Pleistocene human genome from Southwest ChinaCurr. Biol. 2022; 32:3095-3109.e52. Fu, Q. ∙ Meyer, M. ∙ Gao, X. ... DNA analysis of an early modern human from Tianyuan Cave, ChinaProc. Natl. Acad. Sci. USA. 2013; 110:2223-22273. Li, H. ∙ Handsaker, B. ∙ Wysoker, A. ..., 1000 Genome Project Data Processing SubgroupThe Sequence Alignment/Map format and SAMtoolsBioinformatics. 2009; 25:2078-20794.