eLife

1 week ago | elifesciences.org | Lucie Oriol |Melody H. Chao |Grace J Kollman |Dina S. Dowlat

eLife Assessment This manuscript provides convincing evidence derived from diverse state-of-the-art approaches to suggest that non-dopaminergic projection neurons in the ventral tegmental area (VTA) make local synapses.

2 weeks ago | elifesciences.org | Julieta Gomez-Frittelli |Gabrielle Devienne |Lee Travis |Melinda Kyloh

eLife Assessment This important study characterizes the molecular signatures and function of a type of enteric neuron (IPAN) in the mouse colon, identifying molecular markers (Cdh6 and Cdh8) for these cells. A battery of compelling and comprehensive experimental findings suggests data from other species are likely translatable to mice, bridging the abundant literature from humans and other mammals into this experimentally tractable animal model.

3 weeks ago | elifesciences.org | Nicolas Desprat |Monica Gerth |Barbara Ritzl-Rinkenberger |Andrew Farr

eLife Assessment This important study combines convincing evolution experiments with molecular and genetic techniques to study how a genetic lesion in MreB that causes rod-shaped cells to become spherical, with concomitant deleterious fitness effects, can be rescued by natural selection. The detailed mechanistic investigation increases our understanding of how mreB contributes to cell wall synthesis and shows how compensatory mutations may reestablish its homogeneity.

4 weeks ago | elifesciences.org | Adriana Bankston

Main text Since President Trump took office, we have seen a complete disregard for science and technology. The new administration’s attacks on science will severely harm our nation’s competitiveness and gravely weaken and diminish its scientific workforce, with researchers from underrepresented groups being particularly at risk.

1 month ago | elifesciences.org | Sytse J Piersma |Shasha Li |Pamela Wong |Michael Bern

eLife Assessment This study on mouse Ly49 receptors expressed on natural killer (NK) cells shows that Ly49A, in the presence of the corresponding MHC class I allele, can lead to NK cell licensing, thereby providing valuable insights into the mechanisms of NK cell modulation by Ly49 receptors. The work may have significant implications for studies of human killer-cell immunoglobulin-like receptors (KIR) expressing and other NK cells. Overall, the study was well-developed with convincing evidence.