bioRxiv

2 weeks ago | biorxiv.org | Hannah Brown |Imtiazul Islam |Juanfang Ruan |Matthew Baker

AbstractArchaeal tubulin-like cytoskeletal protein CetZ1 is required for rod-cell morphogenesis during the development of motile cells in the model archaeon Haloferax volcanii. It has been unknown whether CetZ1 or its paralogs contribute to motility solely through the effects of rod cell shape on swimming speed, or in other ways too.

2 weeks ago | biorxiv.org | Carrie Stine |David Marcus |Amanda L Pasqualini |Ananya Achanta

AbstractNociceptin/orphanin FQ (N/OFQ), an endogenous opioid neuropeptide, and its G-protein coupled receptor NOPR have been implicated in motivation, feeding behaviors, and aversion. Stress-induced dysfunction in these states is central to the development of numerous psychiatric disorders, and the N/OFQ-NOPR system′s role in reward- and stress-related responses has driven broad interest in NOPR as a therapeutic target for anxiety and depression.

2 weeks ago | biorxiv.org | Caroline Lee |Samantha Cohen |Samuel Hutchinson |Nim Tottenham

AbstractWe investigated how past and current caregiving experiences impacted emotional event processing by examining inter-subject functional correlation in 7- to 15-year-olds during narrative movies depicting separation and reunion. Early adversity impacted amygdala interactions with the hippocampus, but medial prefrontal-amygdala connectivity and the content of later recall was shaped by attachment security to current caregivers.

2 weeks ago | biorxiv.org | |Premal Shah

AbstractAcross taxonomical domains, synonymous codons of an amino acid are found to be used at unequal frequencies within genes. This codon usage bias (CUB) is highly variable across species. Genome-wide CUB reflects a balance between adaptive and non-adaptive microevolutionary processes within a species. Variation in microevolutionary processes results in across-species variation in CUB.

2 weeks ago | biorxiv.org | Yuanzhong Pan |Priscilla Chan |Jeremy Rich |Steve Kay

AbstractGlioblastoma (GBM) remains one of the most aggressive adult cancers, with limited treatment options due to an incomplete understanding of its biology. GBM exhibits different transcriptional subtypes, among which the mesenchymal (mGBM) variant is associated with a particularly aggressive nature and poor outcomes. Developing models that capture mGBM phenotypes could offer new insights into its biology and therapeutic vulnerabilities.