Alberto J Gonzalez-Hernandez

Jun 19, 2024 | onlinelibrary.wiley.com | Kilian Roßmann |Alberto J Gonzalez-Hernandez |Rahul Bhuyan |Caspar Schattenberg

Introduction Photopharmacology represents a powerful means of optically controlling biological function through the use of light-sensitive compounds.1, 2 In addition to its use in a wide variety of basic science applications,3-12 photopharmacology has now entered clinical trials via KIO-301, a photoswitchable ion channel blocker with great potential for vision restoration.13 This compound utilizes an azobenzene-based photoswitch, which represents one of the primary chemical moieties used in...

Jun 11, 2024 | cell.com | Alberto J Gonzalez-Hernandez |Hermany Munguba |Joshua Levitz

Highlights GPCRs operate across highly specialized subcellular compartments in neurons, with the need for precise control of their spatiotemporal properties. G protein-binding proteins can reshape GPCR signaling dynamics through general and receptor-specific mechanisms. GPCRs undergo crosstalk with each other through direct and indirect mechanisms, which are themselves subject to regulation by G protein-binding proteins and receptor-specific scaffolds.

Jan 31, 2024 | nature.com | Gabriele Ciceri |Arianna Baggiolini |Hyein Cho |Alberto J Gonzalez-Hernandez |Hermany Munguba |So Yeon Koo | +3 more

AbstractThe pace of human brain development is highly protracted compared with most other species1,2,3,4,5,6,7. The maturation of cortical neurons is particularly slow, taking months to years to develop adult functions3,4,5. Remarkably, such protracted timing is retained in cortical neurons derived from human pluripotent stem cells (hPSCs) during in vitro differentiation or upon transplantation into the mouse brain4,8,9.