So Yeon Koo

Jan 31, 2024 | nature.com | Gabriele Ciceri |Arianna Baggiolini |Hyein Cho |Alberto J Gonzalez-Hernandez |Hermany Munguba |So Yeon Koo | +3 more

AbstractThe pace of human brain development is highly protracted compared with most other species1,2,3,4,5,6,7. The maturation of cortical neurons is particularly slow, taking months to years to develop adult functions3,4,5. Remarkably, such protracted timing is retained in cortical neurons derived from human pluripotent stem cells (hPSCs) during in vitro differentiation or upon transplantation into the mouse brain4,8,9.

Jan 17, 2024 | cell.com | Liuliu Yang |Manoj Nair |Oliver Harschnitz |Jiajun Zhu |Pengfei Wang |So Yeon Koo | +17 more

hPSC differentiation toward DA neuronsMidbrain dopaminergic neuron differentiation were performed using H9, MEL1 and SNCA different copy numbers hPSCs, which include NURR1: GFP hPSC. hPSCs were grown on VTN-N (Thermo Fisher Scientific)-coated 6-well plates in E8-essential medium. Cells were maintained at 37°C, 5% CO2.