Arianna Baggiolini

May 21, 2024 | nature.com | Hermany Munguba |Arianna Baggiolini |Conor Liston |Shuibing Chen |Gabriele Ciceri

Correction to: Nature Biotechnology https://doi.org/10.1038/s41587-023-02031-z, published online 2 January 2024. In Fig. 3h–k we recorded spontaneous excitatory postsynaptic currents (sEPSCs) in human PSC-derived cortical neurons at either –60 mV or at 0 mV, comparing their synaptic properties following GENtoniK versus DMSO treatment. We reported those currents as either “AMPAR”- or “NMDAR”-mediated, respectively.

Jan 31, 2024 | nature.com | Gabriele Ciceri |Arianna Baggiolini |Hyein Cho |Alberto J Gonzalez-Hernandez |Hermany Munguba |So Yeon Koo | +3 more

AbstractThe pace of human brain development is highly protracted compared with most other species1,2,3,4,5,6,7. The maturation of cortical neurons is particularly slow, taking months to years to develop adult functions3,4,5. Remarkably, such protracted timing is retained in cortical neurons derived from human pluripotent stem cells (hPSCs) during in vitro differentiation or upon transplantation into the mouse brain4,8,9.

Jan 1, 2024 | nature.com | Hermany Munguba |Arianna Baggiolini |Conor Liston |Shuibing Chen |Gabriele Ciceri

AbstractThe maturation of human pluripotent stem cell (hPSC)-derived neurons mimics the protracted timing of human brain development, extending over months to years for reaching adult-like function. Prolonged in vitro maturation presents a major challenge to stem cell-based applications in modeling and treating neurological disease.