Hyein Cho

Sep 1, 2024 | biorxiv.org | Bess P. Rosen |QING LI |Hyein Cho |Dingyu Liu

AbstractPluripotent stem cells are defined by their self-renewal capacity, which is the ability of the stem cells to proliferate indefinitely while maintaining the pluripotent identity essential for their ability to differentiate into any somatic cell lineage. However, understanding the mechanisms that control stem cell fitness versus the pluripotent cell identity is challenging.

Jan 31, 2024 | nature.com | Gabriele Ciceri |Arianna Baggiolini |Hyein Cho |Alberto J Gonzalez-Hernandez |Hermany Munguba |So Yeon Koo | +3 more

AbstractThe pace of human brain development is highly protracted compared with most other species1,2,3,4,5,6,7. The maturation of cortical neurons is particularly slow, taking months to years to develop adult functions3,4,5. Remarkably, such protracted timing is retained in cortical neurons derived from human pluripotent stem cells (hPSCs) during in vitro differentiation or upon transplantation into the mouse brain4,8,9.