Hermany Munguba

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Articles

Emerging modes of regulation of neuromodulatory G protein-coupled receptors

Jun 11, 2024 | cell.com | Alberto J Gonzalez-Hernandez |Hermany Munguba |Joshua Levitz

Highlights GPCRs operate across highly specialized subcellular compartments in neurons, with the need for precise control of their spatiotemporal properties. G protein-binding proteins can reshape GPCR signaling dynamics through general and receptor-specific mechanisms. GPCRs undergo crosstalk with each other through direct and indirect mechanisms, which are themselves subject to regulation by G protein-binding proteins and receptor-specific scaffolds.
Author Correction: Combined small-molecule treatment accelerates maturation of human pluripotent stem cell-derived neurons - Nature Biotechnology

May 21, 2024 | nature.com | Hermany Munguba |Arianna Baggiolini |Conor Liston |Shuibing Chen |Gabriele Ciceri

Correction to: Nature Biotechnology https://doi.org/10.1038/s41587-023-02031-z, published online 2 January 2024. In Fig. 3h–k we recorded spontaneous excitatory postsynaptic currents (sEPSCs) in human PSC-derived cortical neurons at either –60 mV or at 0 mV, comparing their synaptic properties following GENtoniK versus DMSO treatment. We reported those currents as either “AMPAR”- or “NMDAR”-mediated, respectively.
An epigenetic barrier sets the timing of human neuronal maturation - Nature

Jan 31, 2024 | nature.com | Gabriele Ciceri |Arianna Baggiolini |Hyein Cho |Alberto J Gonzalez-Hernandez |Hermany Munguba |So Yeon Koo | +3 more

AbstractThe pace of human brain development is highly protracted compared with most other species1,2,3,4,5,6,7. The maturation of cortical neurons is particularly slow, taking months to years to develop adult functions3,4,5. Remarkably, such protracted timing is retained in cortical neurons derived from human pluripotent stem cells (hPSCs) during in vitro differentiation or upon transplantation into the mouse brain4,8,9.
Combined small-molecule treatment accelerates maturation of human pluripotent stem cell-derived neurons - Nature Biotechnology

Jan 1, 2024 | nature.com | Hermany Munguba |Arianna Baggiolini |Conor Liston |Shuibing Chen |Gabriele Ciceri

AbstractThe maturation of human pluripotent stem cell (hPSC)-derived neurons mimics the protracted timing of human brain development, extending over months to years for reaching adult-like function. Prolonged in vitro maturation presents a major challenge to stem cell-based applications in modeling and treating neurological disease.