Alexander Kurilshikov

Oct 17, 2024 | biorxiv.org | Nataliia Kuzub |Alexander Kurilshikov |Alexandra Zhernakova |Sanzhima Garmaeva

AbstractEnvironmental contamination complicates the study of low-biomass microbial communities like the human gut virome. In 1,321 early-life gut viromes and 55 negative controls (NCs) from four datasets, we identified viral contaminants and their prevalence across studies.

Mar 6, 2024 | nature.com | Minna K. Karjalainen |Eeva Sliz |Elias Allara |Weihua Zhang |Pekka Jousilahti |Kati Kristiansson | +46 more

AbstractGenome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism1,2,3,4,5,6,7. This detailed knowledge of the genetic determinants of systemic metabolism has been pivotal for uncovering how genetic pathways influence biological mechanisms and complex diseases8,9,10,11.

Mar 1, 2024 | nature.com | Sanzhima Garmaeva |Trishla Sinha |Anastasia A. Gulyaeva |Johanne E Spreckels |Sergio Andreu-Sánchez |Ranko Gacesa | +8 more

AbstractEarly development of the gut ecosystem is crucial for lifelong health. While infant gut bacterial communities have been studied extensively, the infant gut virome remains under-explored. To study the development of the infant gut virome over time and the factors that shape it, we longitudinally assess the composition of gut viruses and their bacterial hosts in 30 women during and after pregnancy and in their 32 infants during their first year of life.