Minna K. Karjalainen

Nov 18, 2024 | nature.com | Coraline Borowczyk |Minna Kaikkonen |William Tressel |James B. Stein |Edward B Thorp |Emmanuel L. Gautier | +3 more

AbstractMetabolic dysregulation, including perturbed glutamine–glutamate homeostasis, is common among patients with cardiovascular diseases, but the underlying mechanisms remain largely unknown. Using the human MESA cohort, here we show that plasma glutamine–glutamate ratio is an independent risk factor for carotid plaque progression.

Mar 6, 2024 | nature.com | Minna K. Karjalainen |Eeva Sliz |Elias Allara |Weihua Zhang |Pekka Jousilahti |Kati Kristiansson | +46 more

AbstractGenome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism1,2,3,4,5,6,7. This detailed knowledge of the genetic determinants of systemic metabolism has been pivotal for uncovering how genetic pathways influence biological mechanisms and complex diseases8,9,10,11.

Oct 23, 2023 | journals.plos.org | Anu Pasanen |Minna K. Karjalainen |Ge Zhang |Heli Tiensuu

Loading metrics Open Access Peer-reviewedResearch Article ? This is an uncorrected proof. Citation: Pasanen A, Karjalainen MK, FinnGen, Zhang G, Tiensuu H, Haapalainen AM, et al. (2023) Meta-analysis of genome-wide association studies of gestational duration and spontaneous preterm birth identifies new maternal risk loci. PLoS Genet 19(10): e1010982. https://doi.org/10.1371/journal.pgen.1010982Editor: Vincent J.