Allan Lawrie

Jan 6, 2024 | nature.com | Anna Ulrich |John Wharton |Inês Cebola |Marjo-Riitta Järvelin |Karl-Heinz Herzig |Luke Howard | +7 more

AbstractPulmonary arterial hypertension (PAH) is characterised by pulmonary vascular remodelling causing premature death from right heart failure. Established DNA variants influence PAH risk, but susceptibility from epigenetic changes is unknown. We addressed this through epigenome-wide association study (EWAS), testing 865,848 CpG sites for association with PAH in 429 individuals with PAH and 1226 controls.

Sep 28, 2023 | nature.com | Prakash Chelladurai |Samer Alabed |Carsten Kuenne |Werner Seeger |Mario Looso |Allan Lawrie | +1 more

AbstractRight ventricular (RV) function is critical to prognosis in all forms of pulmonary hypertension. Here we perform molecular phenotyping of RV remodeling by transcriptome analysis of RV tissue obtained from 40 individuals, and two animal models of RV dysfunction of both sexes.