Prakash Chelladurai

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ATP citrate lyase drives vascular remodeling in systemic and pulmonary vascular diseases through metabolic and epigenetic changes

Dec 11, 2024 | science.org | Yann Grobs |Charlotte Romanet |Sarah-Eve Lemay |Alice Bourgeois |Pierre Voisine |Sandra Breuils-Bonnet | +7 more
Transcriptional profiling unveils molecular subgroups of adaptive and maladaptive right ventricular remodeling in pulmonary hypertension - Nature Cardiovascular Research

Sep 28, 2023 | nature.com | Prakash Chelladurai |Samer Alabed |Carsten Kuenne |Werner Seeger |Mario Looso |Allan Lawrie | +1 more

AbstractRight ventricular (RV) function is critical to prognosis in all forms of pulmonary hypertension. Here we perform molecular phenotyping of RV remodeling by transcriptome analysis of RV tissue obtained from 40 individuals, and two animal models of RV dysfunction of both sexes.

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