Mario Looso

Sep 12, 2024 | nature.com | Stefan Günther |Mario Looso

AbstractThe innate immune response is triggered rapidly after injury and its spatiotemporal dynamics are critical for regeneration; however, many questions remain about its exact role. Here we show that MyD88, a key component of the innate immune response, controls not only the inflammatory but also the fibrotic response during zebrafish cardiac regeneration.

Sep 28, 2023 | nature.com | Prakash Chelladurai |Samer Alabed |Carsten Kuenne |Werner Seeger |Mario Looso |Allan Lawrie | +1 more

AbstractRight ventricular (RV) function is critical to prognosis in all forms of pulmonary hypertension. Here we perform molecular phenotyping of RV remodeling by transcriptome analysis of RV tissue obtained from 40 individuals, and two animal models of RV dysfunction of both sexes.