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Dec 5, 2024 | 
nature.com | Elias Allara |Steven Bell |Dipender Gill |Liam Gaziano |Feiyi Wang |Vinicius Tragante | +30 more
AbstractIron homoeostasis is tightly regulated, with hepcidin and soluble transferrin receptor (sTfR) playing significant roles. However, the genetic determinants of these traits and the biomedical consequences of iron homoeostasis variation are unclear. In a meta-analysis of 12 cohorts involving 91,675 participants, we found 43 genomic loci associated with either hepcidin or sTfR concentration, of which 15 previously unreported.
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Dec 5, 2024 | nature.com | Elias Allara |Steven Bell |Dipender Gill |Liam Gaziano |Feiyi Wang |Vinicius Tragante | +30 more
AbstractIron homoeostasis is tightly regulated, with hepcidin and soluble transferrin receptor (sTfR) playing significant roles. However, the genetic determinants of these traits and the biomedical consequences of iron homoeostasis variation are unclear. In a meta-analysis of 12 cohorts involving 91,675 participants, we found 43 genomic loci associated with either hepcidin or sTfR concentration, of which 15 previously unreported.
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Dec 5, 2024 | nature.com | Elias Allara |Steven Bell |Dipender Gill |Liam Gaziano |Feiyi Wang |Vinicius Tragante | +30 more
AbstractIron homoeostasis is tightly regulated, with hepcidin and soluble transferrin receptor (sTfR) playing significant roles. However, the genetic determinants of these traits and the biomedical consequences of iron homoeostasis variation are unclear. In a meta-analysis of 12 cohorts involving 91,675 participants, we found 43 genomic loci associated with either hepcidin or sTfR concentration, of which 15 previously unreported.
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Jul 31, 2024 | 
nature.com | Samantha Ip |Fatemeh Torabi |Hoda Abbasizanjani |Ashley Akbari |Rachel Denholm |AMITAVA BANERJEE | +4 more
AbstractThe first dose of COVID-19 vaccines led to an overall reduction in cardiovascular events, and in rare cases, cardiovascular complications. There is less information about the effect of second and booster doses on cardiovascular diseases.
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Jun 27, 2024 | 
lexology.com | Angela Wood |Andy Bubb
The Pepsi decision changes the approach for determining if taxpayers are liable to withholding tax in Australia for IP use, particularly where trade marks are involved so multinationals operating in Australia will need to continue reviewing their arrangements to determine their level of risk that royalty withholding tax or the DPT might apply.
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Mar 11, 2024 | 
nature.com | Genevieve Cezard |Rochelle Knight |Yinghui Wei |Renin Toms |Alex Walker |Jon Massey | +8 more
AbstractInfection with SARS-CoV-2 is associated with an increased risk of arterial and venous thrombotic events, but the implications of vaccination for this increased risk are uncertain. With the approval of NHS England, we quantified associations between COVID-19 diagnosis and cardiovascular diseases in different vaccination and variant eras using linked electronic health records for ~40% of the English population.
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Jan 19, 2024 | 
jamanetwork.com | Guoyi Yang |Amy Mason |Angela Wood
Key PointsQuestion Do apolipoprotein B (apoB), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) increase risk of coronary artery disease (CAD), all-cause mortality, or cause-specific mortality, and if so, what are the shapes of these associations?
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Dec 22, 2023 | 
lexology.com | Angela Wood |Alexandra Adams
NSW Premier Chris Minns has now established the Special Commission of Inquiry into Healthcare Funding that formed a key election promise. Mr Richard Beasley SC has been appointed as Commissioner of the Inquiry. The Letters Patent establishing the Inquiry were issued on 24 August 2023 with a view to having the Inquiry provide a final report by 24 August 2024. The purpose of the inquiry is to conduct a holistic review of the funding of health services in NSW.
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Dec 12, 2023 | 
nature.com | Josef Fritz |Tone Bjørge |Angela Wood |Christel Häggström |Hanno Ulmer |Gabriele Nagel | +3 more
AbstractInsulin resistance is a hypothesised biological mechanism linking obesity with prostate cancer (PCa) death. Data in support of this hypothesis is limited. We included 259,884 men from eight European cohorts, with 11,760 incident PCa’s and 1784 PCa deaths during follow-up. We used the triglyceride-glucose (TyG) index as indicator of insulin resistance.
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Nov 3, 2023 | 
asmallworld.com | Angela Wood
Celebrate the festive season at a Wild West themed Christmas market in Bavaria. Head to the top of a mountain in Switzerland, see driftwood sculptures in France or sail to a remote island for glühwein and seasonal handicrafts! Here are a few of the most unusual festive markets to check out in Europe this winter. In the pretty town of Evian les Bains in France, you’ll be welcomed into a wonderland of driftwood this Christmas.
