Annie V. Rorick

Jan 23, 2025 | cell.com | Eric Wang |Alexander Cohen |Luis F. Caldera |Jennifer R. Keeffe |Annie V. Rorick |Yusuf M. Adia | +3 more

Keywordsantibodycomputational methodsnanoparticleprotein designRBDsarbecovirusSARS-CoV-2vaccinationIntroductionEmerging SARS-CoV-2 variants, notably Omicron and its subvariants, have demonstrated the ability to partially evade previous vaccine-induced immune responses by mutating epitopes targeted by the generated antibodies,1,2,3,4,5,6,7,8,9 thus extending the duration and impact of the COVID-19 pandemic.

May 6, 2024 | nature.com | Rory A Hills |Tiong Kit Tan |Alexander Cohen |Jennifer R. Keeffe |Michelle Hill |Madeeha Afzal | +7 more

AbstractDefending against future pandemics requires vaccine platforms that protect across a range of related pathogens. Nanoscale patterning can be used to address this issue. Here, we produce quartets of linked receptor-binding domains (RBDs) from a panel of SARS-like betacoronaviruses, coupled to a computationally designed nanocage through SpyTag/SpyCatcher links.