Daniel Reeves

Oct 2, 2023 | nature.com | Daniel Reeves |Mohamed Abdel-Mohsen |Mars Stone |Frederick M. Hecht |Jeffrey Martin |Steven Deeks | +2 more

AbstractPersistence of HIV in people living with HIV (PWH) on suppressive antiretroviral therapy (ART) has been linked to physiological mechanisms of CD4+ T cells. Here, in the same 37 male PWH on ART we measure longitudinal kinetics of HIV DNA and cell turnover rates in five CD4 cell subsets: naïve (TN), stem-cell- (TSCM), central- (TCM), transitional- (TTM), and effector-memory (TEM). HIV decreases in TTM and TEM but not in less-differentiated subsets.

Jul 13, 2023 | nature.com | Daniel Reeves |Thiago Oliveira |Michael J Peluso |Joshua T Schiffer |Steven Deeks

Human participantsThis study was approved by the institutional review board of the NIH National Institute of Allergy and Infectious Diseases and registered on ClinicalTrials.gov: NCT00039689. All study participants provided written informed consent, and leukapheresis products were collected in accordance with the protocol. All study participants were of male sex based on self-reporting. 5 participants were White, 3 Black and 2 Unknown/Hispanic-Latino.