Dianjianyi Sun

2 months ago | nature.com | Neil Wright |Hannah Fry |Yiping Chen |Huaidong Du |Canqing Yu |Dianjianyi Sun | +6 more

AbstractProteomics offers unique insights into human biology and drug development, but few studies have directly compared the utility of different proteomics platforms. We measured plasma levels of 2168 proteins in 3976 Chinese adults using both Olink Explore and SomaScan platforms. The correlation of protein levels between platforms was modest (median rho = 0.29), with protein abundance and data quality parameters being key factors influencing correlation.

Dec 30, 2024 | thelancet.com | Canqing Yu |Dianjianyi Sun |Pei Pei |Yiping Chen

Keywords Chronic obstructive pulmonary disease Restrictive lung function Forced expiratory volume in one second Cardiovascular disease Obesity Underweight Evidence before this study We searched PubMed for existing articles published from inception to January 19, 2024, using spirometric pattern-related terms (“COPD” OR “airflow obstruction” OR “restrictive spirometric pattern”) and outcome terms (“cardiovascular disease” OR “heart disease” OR “heart failure” OR “cerebrovascular disease” OR...

Sep 29, 2024 | nature.com | Canqing Yu |Robin G Walters |Zhengming Chen |Dianjianyi Sun

AbstractLittle is known about the prospective association between autosomal mosaic chromosomal alterations (mCAs), a group of large-scale somatic mutations on autosomes, and bladder cancer. Here we utilized data from 99,877 participants who were free of physician-diagnosed cancer at baseline (2004–2008) of the China Kadoorie Biobank to estimate the associations between autosomal mCAs and bladder cancer (ICD-10: C67). A total of 2874 autosomal mCAs events among 2612 carriers (2.6%) were detected.

Jun 14, 2024 | thelancet.com | Yuanyuan Chen |Wei Yu |Jun Lv |Dianjianyi Sun

Research in contextEvidence before this studyWe searched PubMed, EMBASE, and Google Scholar for full-length articles published from the inception of each database to May 31, 2023, with a combination of terms: (“body mass index” OR “BMI” OR “weight” OR “overweight” OR “obesity”) AND (“young” OR “early adulthood” OR “late adolescent”) AND (“lifestyle” OR “smoking” OR “tobacco use” OR “alcohol” OR “physical activity” OR “diet”). No restrictions were applied to study type or language.

Mar 8, 2024 | nature.com | Dianjianyi Sun |Iona Y. Millwood |Robin G Walters |Yiping Chen |Huaidong Du |Zhengming Chen | +1 more

AbstractDespite the high prevalence of snoring in Asia, little is known about the genetic etiology of snoring and its causal relationships with cardiometabolic traits. Based on 100,626 Chinese individuals, a genome-wide association study on snoring was conducted. Four novel loci were identified for snoring traits mapped on SLC25A21, the intergenic region of WDR11 and FGFR, NAA25, ALDH2, and VTI1A, respectively.